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The fate and mobility of chromium, arsenic and zinc in municipal sewage sludge during the co-pyrolysis process with organic and inorganic chlorides.
Sci Rep
January 2025
Institute of Science and High Technology and Environmental Sciences, Graduate University of Advanced Technology, Kerman, Iran.
Co-pyrolysis is an efficient approach for municipal sewage sludge (SS) treatment, facilitating the production of biochar and promoting the stabilization and removal of heavy metals, particularly when combined with chlorinated materials. This study explores the impact of pyrolysis temperatures (400 °C and 600 °C) and chlorinated additives (polyvinyl chloride (PVC) as an organic chloride source and ferric chloride (FeCl) as an inorganic chloride source) at 10% and 20% concentrations, on the yield, chemical speciation, leachability, and ecological risks of arsenic (As), chromium (Cr), and zinc (Zn) in biochar derived from SS. The results revealed that increasing the pyrolysis temperature from 400 to 600 °C significantly reduced biochar yield due to enhanced volatilization of organic components, as well as the removal of heavy metals in interaction with chlorinated materials.
View Article and Find Full Text PDFExploiting YES1-driven EGFR expression improves the efficacy of EGFR inhibitors.
Mol Cancer Res
January 2025
Cleveland Clinic, Cleveland, OH, United States.
Epidermal growth factor receptor (EGFR) is a highly expressed driver of many cancers, yet the utility of EGFR inhibitors is limited to cancers that harbor sensitizing mutations in the EGFR gene due to dose limiting toxicities. Rather than conventionally blocking the kinase activity of EGFR, we sought to reduce its transcription as an alternative approach to broaden the therapeutic window for EGFR inhibitors targeting wildtype or mutant EGFR. We found that YES1 is highly expressed in triple negative breast cancer (TNBC) and drives cell growth by elevating EGFR levels.
View Article and Find Full Text PDFA meta-analysis of genome-wide association studies to identify candidate genes associated with feed efficiency traits in pigs.
J Anim Sci
January 2025
Department of Animal Science, Federal University of Viçosa, Viçosa, MG, 36570-900, Brazil.
Pig production is an agricultural sector of great economic and social relevance to Brazil and global markets. Feed efficiency traits directly influence the sustainability of pig production due to the economic impact of feed costs on the production system and the environmental footprint of the industry. Therefore, breeding for improved feed efficiency has been a target of worldwide pig breeding programs.
View Article and Find Full Text PDFWeathering the Pain: Ambient Temperature's Role in Chronic Pain Syndromes.
Curr Pain Headache Rep
January 2025
Department of Physical Medicine & Rehabilitation, New York University Langone Health, New York, NY, USA.
Purpose Of Review: Chronic pain is highly prevalent and involves a complex interaction of sensory, emotional, and cognitive processes, significantly influenced by ambient temperature. Despite advances in pain management, many patients continue to experience inadequate pain relief. This review aims to consolidate and critically evaluate the current evidence on the impact of ambient temperature on chronic pain conditions such as fibromyalgia (FM), multiple sclerosis (MS), complex regional pain syndrome (CRPS), and osteoarthritis (OA).
View Article and Find Full Text PDFReal-time mechanism-based interventions for daily alcohol challenges: Protocol for ecological momentary assessment and intervention.
Digit Health
January 2025
Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany.
Background: Advancing evidence-based, tailored interventions for substance use disorders (SUDs) requires understanding temporal directionality while upholding ecological validity. Previous studies identified loneliness and craving as pivotal factors associated with alcohol consumption, yet the precise directionality of these relationships remains ambiguous.
Objective: This study aims to establish a smartphone-based real-life intervention platform that integrates momentary assessment and intervention into everyday life.
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