AI Article Synopsis

  • - The study aimed to evaluate whether Helicobacter pylori (H pylori) infection affects homocysteine levels by altering vitamin B(12) and folate levels, and if eradicating H pylori reduces homocysteine.
  • - Conducted with 73 dyspeptic H pylori-positive patients, 41 patients successfully eradicated H pylori after treatment, and their serum levels of vitamin B(12), folate, and homocysteine were measured before and after therapy.
  • - Results showed that patients who successfully eradicated H pylori had increased vitamin B(12) and erythrocyte folate, along with decreased homocysteine levels post-treatment, indicating a connection among these

Article Abstract

Aim: To determine whether Helicobacter pylori (H pylori)infection caused hyperhomocysteinemia by altering serum vitamin B(12), serum folate and erythrocyte folate levels and whether eradication of this organism decreased serum homocysteine level.

Methods: The study involved 73 dyspeptic H pylori-positive patients, none of them had gastric mucosal atrophy based on rapid urease test and histology. Out of 73 patients, 41 (56.2%) showed a successful eradication of H pylori 4 wk after the end of treatment. In these 41 patients, fasting serum vitamin B(12), folate and homocysteine levels, and erythrocyte folate levels before and 4 wk after H pylori eradication therapy were compared.

Results: The group with a successful eradication of H pylori had significantly higher serum vitamin B(12) and erythrocyte folate levels in the post-treatment period compared to those in pre-treatment period (210+/-97 pg/mL vs 237+/-94 pg/mL, P<0.001 and 442+/-212 ng/mL vs 539+/-304 ng/mL, P = 0.024, respectively), but showed no significant change in serum folate levels (5.6+/-2.6 ng/mL vs 6.0+/-2.4 ng/mL, P = 0.341). Also, the serum homocysteine levels in this group were significantly lower after therapy (13.1+/-5.2 micromol/L vs 11.9+/-6.2 micromol /L, P = 0.002). Regression analysis showed that serum homocysteine level was positively correlated with age (P = 0.01) and negatively with serum folate level before therapy (P = 0.003).

Conclusion: Eradication of H pylori decreases serum homocysteine even in patients who do not exhibit gastric mucosal atrophy. It appears that the level of homocysteine in serum is related to a complex interaction among serum vitamin B(12), serum folate and erythrocyte folate levels.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4305912PMC
http://dx.doi.org/10.3748/wjg.v11.i18.2764DOI Listing

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