An analysis for manned missions targeted to the Jovian system has been performed in the framework of the NASA RASC (Revolutionary Aerospace Systems Concepts) program on Human Exploration beyond Mars. The missions were targeted to the Jupiter satellite Callisto. The mission analysis has been divided into three main phases, namely the interplanetary cruise, the Jupiter orbital insertion, and the surface landing and exploration phases. The interplanetary phase is based on departure from the Earth-Moon L1 point. Interplanetary trajectories based on the use of different propulsion systems have been considered, with resulting overall cruise phase duration varying between two and five years. The Jupiter-approach and the orbital insertion trajectories are considered in detail, with the spacecraft crossing the Jupiter radiation belts and staying around the landing target. In the surface exploration phase the stay on the Callisto surface is considered. The satellite surface composition has been modeled based on the most recent results from the GALILEO spacecraft. In the transport computations the surface backscattering has been duly taken into account. Particle transport has been performed with the HZETRN heavy ion code for hadrons and with an in-house developed transport code for electrons and bremsstrahlung photons. The obtained doses have been compared to dose exposure limits.
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http://dx.doi.org/10.1016/j.asr.2003.09.061 | DOI Listing |
Dokl Biochem Biophys
January 2025
Institute of Biomedical Problems, Russian Academy of Sciences, 123007, Moscow, Russia.
One of the most obvious manifestations of the negative impact of space flight factors on the human physiology is osteopenia. With the active development of manned space flights and the increase in the duration of humans' persistence in weightlessness, there is a growing need to understand the mechanisms of changes occurring at the cellular level involved in the replenishment of bone tissue. Using the RNA sequencing method, changes in the transcriptome profile of MMSCs were studied after a 5-day simulation of the microgravity effects.
View Article and Find Full Text PDFNutrients
December 2024
State Key Laboratory of Space Medicine, China Astronaut Research and Training Center, Beijing 100094, China.
Background: Long-term fasting demonstrates greater therapeutic potential and broader application prospects in extreme environments than intermittent fasting.
Method: This pilot study of 10-day complete fasting (CF), with a small sample size of 13 volunteers, aimed to investigate the time-series impacts on gut microbiome, serum metabolome, and their interrelationships with biochemical indices.
Results: The results show CF significantly affected gut microbiota diversity, composition, and interspecies interactions, characterized by an expansion of the Proteobacteria phylum (about six-fold) and a decrease in Bacteroidetes (about 50%) and Firmicutes (about 34%) populations.
Health Sci Rep
January 2025
Faculty of Medicine and Health Science Crewe Campus, University of Buckingham Crewe UK.
Background: Space exploration has become a major interest for scientific and medical research. With increasing duration and frequency of manned space missions, it is crucial to understand the impact of microgravity on the cardiovascular health of astronauts. We focus on this relationship by reviewing literature that explores how microgravity affects several hemodynamic parameters and cardiovascular biomarkers.
View Article and Find Full Text PDFCommun Biol
December 2024
MARE - Marine and Environmental Sciences Centre, ARNET - Aquatic Research Network, Agência Regional para o Desenvolvimento da Investigação Tecnologia e Inovação (ARDITI), Funchal, Madeira, Portugal.
The mesophotic zone represents one of our planet's largest and least explored biomes. An increasing number of studies evidence the importance of macrofouling species in marine ecosystems, but information on these communities and the factors influencing their structures at mesophotic depths remain poor. This lack of understanding limits our ability to predict anthropogenic impacts or conduct restoration operations in the mesophotic and the lower boundary of the euphotic zones.
View Article and Find Full Text PDFSci Rep
November 2024
State Key Laboratory of Space Medicine, Astronaut Research and Training Center, 100094, Beijing, China.
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