AI Article Synopsis
- The study evaluated the cytotoxic and antioxidant effects of Achillea alexandri-regis herb extracts, revealing that combined chloroform and ethylacetate extracts were highly effective against HeLa cancer cells.
- The methanol extract showed moderate cytotoxic effects on both HeLa and K562 leukemia cells, but did not harm non-malignant peripheral blood mononuclear cells (PBMC).
- Additionally, the methanol extract exhibited significant antioxidant properties, demonstrating concentration-dependent DPPH radical scavenging activity.
Article Abstract
The cytotoxicity and antioxidant properties of herb extracts of Achillea alexandri-regis were studied. Combined chloroform and ethylacetate extracts exhibited a pronounced cytotoxic effect against HeLa cancer cells (IC50 = 25.92 +/- 4.96 microg/ml), and lower cytotoxicity against K562 leukemia cells (IC50 = 48.59 +/- 18.31 microg/ml). The methanol extract was found to be a moderately cytotoxic in vitro agent against HeLa and K562 cells. No suppressive activity was detected on non-malignant peripheral blood mononuclear cells (PBMC). The antioxidant activity of the methanol extract was assessed by DPPH radical scavenging. The methanol extract of A. alexandri-regis showed concentration dependent DPPH radical scavenging activity with IC50 = 36.14 +/- 0.05 microg/ml.
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