Purpose: To describe methods for measuring interocular latency differences of multifocal visual evoked potentials (mfVEP) and for determining regions with abnormal interocular latencies in patients.
Methods: The mfVEPs from 100 individuals with normal visual fields and normal fundus examinations were analyzed. Individuals ranged in age from 21.6 to 92.4 years. The stimulus was a 60 sector, pattern-reversing dartboard display. Each sector had 16 checks, 8 white (200 cd/m2) and 8 black (< 1 cd/m2). Interocular latency was measured as the temporal shift producing the best cross-correlation value between the corresponding responses of each eye. The 'corrected interocular latency' was defined as the difference between this shift and the mean interocular latency (shift) for a particular sector and recording channel.
Results: The variability of the corrected interocular latency decreased as the signal-to-noise ratio (SNR) of the mfVEP responses increased. For example, the 95% confidence intervals decreased from over 16 ms to under 4 ms as SNR increased. Grouping and summing the responses also lead to an increase in SNR and a decrease in the confidence interval. The results of various cluster criteria were also derived. A cluster criterion (e.g. two or more contiguous points within a hemisphere exceeding a given confidence interval), can serve to increase the specificity for detection of eyes or individuals with abnormal interocular latencies. For example, while 21% of the eyes had 3 or more points exceeding the 5% confidence interval, only 1.8% of the eyes had a cluster of 3 or more of these points. Finally, interocular latency was only weakly correlated with age (r = 0.26).
Conclusion: In testing for abnormalities in interocular latencies, the confidence interval should be based upon the SNR of the response. Grouping and summing responses to increase SNR or employing a cluster test may also prove useful.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s10633-004-5511-1 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Article Synopsis
- Visual evoked potential (VEP) is a non-invasive method used to identify visual system abnormalities, particularly useful for young children who can't communicate visual issues.
- The study involved 60 schoolchildren aged 7-12, analyzing VEPs to assess the optic pathway by measuring the latency and amplitude of specific components (P100, N70, N155).
- Results indicated that a significant portion of children had extended P100 latency, suggesting possible underlying visual disorders, while those with normal VEPs had a healthy visual pathway.
Assessing the visual afferent pathway with the multifocal visual evoked potentials in the radiologically isolated syndrome.
Sci Rep
August 2024
Department of Surgery, Medical and Social Sciences, University of Alcalá, 28805, Alcalá de Henares, Madrid, Spain.
The early identification of individuals with radiologically isolated syndrome (RIS) who are at an elevated risk of progressing to multiple sclerosis (MS) is essential for making informed treatment decisions. This study aimed to evaluate the predictive potential of multifocal Visual Evoked Potentials (mfVEP) measures in individuals with RIS with respect to their conversion to MS. A prospective observational cohort study was conducted, involving 21 individuals with RIS recruited from a MS center.
View Article and Find Full Text PDFNon-Invasive Recording of Ocular-Following Responses in Children: A Promising Tool for Stereo Deficiency Evaluation.
J Clin Med
March 2024
Department of Ophthalmology, Institute for Maternal and Child Health-IRCCS "Burlo Garofolo", 34137 Trieste, Italy.
The ability to merge the two retinal images to perceive depth (stereopsis) plays an important role in human vision. Its proper development requires binocular alignment and good visual acuity in both eyes during childhood. Because treatments are more effective when applied early, early diagnosis is important.
View Article and Find Full Text PDFPeering further into the mind's eye: combining visual evoked potential and optical coherence tomography measures enhances insight into the variance in cognitive functioning in multiple sclerosis.
J Neurol
February 2024
South Shore Neurologic Associates, New York University, Patchogue, New York, NY, USA.
Background: Spectral Optical Coherence Tomography (OCT) and Visual Evoked Potentials (VEPs) have both emerged as potentially useful biomarkers of cognitive decline in people with multiple sclerosis (PwMS). Their combined use may provide additional predictive value for identifying disease impact, progression, and remyelination capacity above-and-beyond what is captured using either approach alone.
Objective: We examined the relationship between OCT/VEP measures and cognitive functioning in 205 PwMS.
Revisiting the effects of configuration, predictability, and relevance on visual detection during interocular suppression.
Cognition
September 2023
Department of Psychology & Cognitive Science Program, Cornell University, Ithaca, NY, United States of America.
Statistical regularities and predictions can influence the earliest stages of visual processing. Studies examining their effects on detection, however, have yielded inconsistent results. In continuous flash suppression (CFS), where a static image projected to one eye is suppressed by a dynamic image presented to the other, the predictability of the suppressed signal may facilitate or delay detection.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!