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Investigating the role and mechanisms of bisphenol compounds in premature ovarian insufficiency using computational biology and bioinformatics.
Ecotoxicol Environ Saf
January 2025
Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China; National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital), Beijing, China. Electronic address:
Premature Ovarian Insufficiency refers to the premature decline in ovarian function before the age of 40, resulting in menstrual irregularities or complete cessation of menstruation, and affecting fertility. Widely used bisphenol compounds may have potential health effects, including premature ovarian insufficiency (POI). This study employs computational biology and bioinformatics to investigate the effects of bisphenols (BPs) on POI.
View Article and Find Full Text PDFThe impact of bisphenol A on gill health: A focus on mitochondrial dysfunction induced disorders of energy metabolism and apoptosis in Meretrix petechialis.
Aquat Toxicol
January 2025
School of Marine Science and Fisheries, Jiangsu Ocean University, Lianyungang, Jiangsu 222005, China; Marine Resources Development Institute of Jiangsu, Jiangsu Ocean University, Lianyungang, Jiangsu 222005, China. Electronic address:
Bisphenol A (BPA), a well-known chemical compound used in various daily goods, has been associated with adverse effects on animal metabolic processes. However, the specific impacts of BPA exposure on clam gills remain largely unexplored. To investigate the effects of BPA on energy metabolism and apoptosis in Meretrix petechialis gills, clams were exposed to varying concentrations of BPA (1, 10, and 100 μg/L) for 21 days.
View Article and Find Full Text PDFMammary Gland Reactive Stroma Characterization at Aging After Bisphenol A Exposure During Hormonal Susceptibility Windows.
Cell Biol Int
January 2025
Microscopy and Microanalysis Center, Institute of Biosciences, Letters and Exact Sciences (IBILCE), São Paulo State University (Unesp), São José do Rio Preto, SP, Brazil.
Mammary glands development is influenced by endocrine signaling, which remodels epithelial and stromal compartments. Reactive stroma phenotype is observed when stromal disturbances occur, leading to changes in extracellular matrix composition and occurrence of reactive cell types. One of the triggers of these alterations is endocrine-disrupting chemical exposure, such as bisphenol A (BPA).
View Article and Find Full Text PDFMajor heavy metals and human gut microbiota composition: a systematic review with nutritional approach.
J Health Popul Nutr
January 2025
Department of Clinical Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.
Background: The human gut microbiota has a critical role in several aspects of host homeostasis, such as immune development, metabolism, nutrition, and defense against pathogens during life. It can be sensitive to xenobiotics including drugs, diet, or even environmental pollutants, especially heavy metals (HMs). The findings of some previous studies are heterogeneous due to the inclusion of various types of study (human, and animal studies) and wide exposures (phthalate, bisphenol A, HMS, etc.
View Article and Find Full Text PDFLYVE1 and IL1RL1 are mitochondrial permeability transition-driven necrosis-related genes in heart failure.
Int J Biochem Cell Biol
January 2025
Department of Cardiovascular Surgery, Fujian Medical University Union Hospital, Fuzhou, China; Key Laboratory of Cardio-Thoracic Surgery (Fujian Medical University), Fujian Province University, Fuzhou, China. Electronic address:
Background: Heart failure is linked to increased hospitalization and mortality. Mitochondrial permeability transition-driven necrosis is associated with cardiovascular diseases, but its role in heart failure is unclear. This study aimed to identify and validate genes related to mitochondrial permeability transition-driven necrosis in heart failure, potentially leading to new drug targets and signaling pathways.
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