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Background: Limbic-predominant age-related TDP-43 encephalopathy neuropathological change (LATE-NC) is common in older adults and has been associated with substantial cognitive impairment. However, the association of LATE-NC with brain morphometry has not been thoroughly investigated. In this work, we examined the association of LATE-NC with brain morphometric anomalies using deformation-based morphometry (DBM) in a large community cohort of older adults that came to autopsy (N=897).
View Article and Find Full Text PDFBackground: Alzheimer's disease neuropathologic change (AD-NC) and limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC) are common in older adults and have been associated with brain atrophy, cognitive decline, and dementia. Since AD-NC and LATE-NC are often comorbid and due to the fact that LATE-NC can only be detected at autopsy, in this work, we combined deformation-based morphometry (DBM) on ex-vivo brain MRI and detailed neuropathological evaluation in a large number of community-based older adults to investigate the difference in brain atrophy patterns associated with AD-NC and LATE-NC.
Method: Cerebral hemispheres from 912 older adults participating in four longitudinal, clinical-pathologic cohort studies of aging were included in this work: MAP, ROS, MARS, and AA Core of the Rush Alzheimer's Disease Research Center (Rush ADRC) (Figure 1).
Alzheimer's Imaging Consortium.
Alzheimers Dement
December 2024
Illinois Institute of Technology, Chicago, IL, USA.
Background: Limbic-predominant age-related TDP-43 encephalopathy neuropathological change (LATE-NC) is common in older adults and has been associated with substantial cognitive impairment. However, the association of LATE-NC with brain morphometry has not been thoroughly investigated. In this work, we examined the association of LATE-NC with brain morphometric anomalies using deformation-based morphometry (DBM) in a large community cohort of older adults that came to autopsy (N=897).
View Article and Find Full Text PDFAlzheimer's Imaging Consortium.
Alzheimers Dement
December 2024
Illinois Institute of Technology, Chicago, IL, USA.
Background: Alzheimer's disease neuropathologic change (AD-NC) and limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC) are common in older adults and have been associated with brain atrophy, cognitive decline, and dementia. Since AD-NC and LATE-NC are often comorbid and due to the fact that LATE-NC can only be detected at autopsy, in this work, we combined deformation-based morphometry (DBM) on ex-vivo brain MRI and detailed neuropathological evaluation in a large number of community-based older adults to investigate the difference in brain atrophy patterns associated with AD-NC and LATE-NC.
Method: Cerebral hemispheres from 912 older adults participating in four longitudinal, clinical-pathologic cohort studies of aging were included in this work: MAP, ROS, MARS, and AA Core of the Rush Alzheimer's Disease Research Center (Rush ADRC) (Figure 1).
Alzheimer's Imaging Consortium.
Alzheimers Dement
December 2024
Illinois Institute of Technology, Chicago, IL, USA.
Background: Brain arteriolosclerosis is characterized by the thickening of vessel walls and arteriolar stenosis and is one of the primary pathologies of cerebral small vessel disease. Arteriolosclerosis is linked to lower cognitive and motor function, as well as an elevated risk of dementia. This study aimed to investigate the association of brain arteriolosclerosis with regional gray matter volumes in a large number of community-based older adults.
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