Four children are presented with Class II pancreas injury as a result of a motor vehicle accident. The first child was taken to the operating room promptly due to concomitant perforation of the hollow viscus (gastric rupture) and underwent successful spleen-sparing distal pancreatectomy with preservation of the splenic artery and vein. The next three cases with isolated abdominal symptoms of pancreatic injury generally experienced a delay of one day before the onset of abdominal symptoms and positive diagnostic investigation results and were managed non-operatively (NOM) on admission; they were then treated surgically due to developing peritonitis after 24, 36, and 38 hours, respectively. The same type of operation, even though delayed and technically much more demanding, was performed, but this was not an obstacle to our efforts to preserve the spleen and its full circulation, in order to provide full immunological and haematological support during the expected prolonged postoperative course. We did not lose any of the children. A reintervention was needed in two children due to the retention of necrotic tissue and intraabdominal abscess. The serum amylase level in all cases remained above normal. We believe that a spleen-preserving distal pancreatectomy with splenic vessel conservation can be safely performed, even in delayed operations, and should be indicated for the surgical management.
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http://dx.doi.org/10.1055/s-2004-830345 | DOI Listing |
Cureus
December 2024
Department of Upper Gastrointestinal and Hepatobiliary Surgery, Monash Health, Melbourne, AUS.
Atraumatic splenic rupture (ASR) is a rare and life-threatening condition that presents diagnostic difficulties due to its rarity and non-specific clinical symptoms. It often requires computed tomography (CT) imaging for accurate diagnosis and surgical planning. Splenectomy is the standard treatment for unstable patients, but autotransplantation of splenic tissue may reduce the lifelong risks of overwhelming post-splenectomy infections (OPSI) by preserving some immunological function.
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January 2025
Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia.
Introduction: The gut microbiota plays a pivotal role in influencing host health, through the production of metabolites and other key signalling molecules. While the impact of specific metabolites or taxa on host cells is well-documented, the broader impact of a disrupted microbiota on immune homeostasis is less understood, which is particularly important in the context of the increasing overuse of antibiotics.
Methods: Female C57BL/6 mice were gavaged twice daily for four weeks with Vancomycin, Polymyxin B, or PBS (control).
Drug Des Devel Ther
January 2025
The Second Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou, 310053, People's Republic of China.
Background: Huanglian-ejiao decoction (HED) is a Chinese traditional medicinal formula evolved from the Shanghan Lun (Treatise on Febrile Diseases). However, HED ultimate mechanism of action remained indistinct. Therefore, this study aimed to investigate whether HED could exert anti-inflammatory effects on 2,4,6-Trinitrobenzenesulfonic acid (TNBS)-induced colitis (UC) model through the regulation of CD4T subsets and gut microbiota.
View Article and Find Full Text PDFFood Chem
January 2025
State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730000, China; State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China. Electronic address:
Bacteriophages are promising alternatives for combating multidrug-resistant bacterial infections. Two lytic bacteriophages, named P1 and P3, targeting pathogenic Escherichia coli (ExPEC; strain TZ1_3) were isolated and evaluated for their potential ability to control pathogenic numbers either in ExPEC-contaminated food or ExPEC-infected mice. Results showed that phages significantly reduced ExPEC numbers within 6 and 12 h in contaminated water, milk, beef, and chicken when applied at 10 plaque-forming units (PFU).
View Article and Find Full Text PDFAnn Surg Oncol
January 2025
Division of Pancreatic Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Introduction: Laparoscopic distal pancreatectomy (LDP) has the advantages of reduced blood loss, shorter hospital stays, and a better postoperative quality of life compared with open distal pancreatectomy (ODP). Meanwhile, spleen-preserving laparoscopic distal pancreatectomy is the preferred technique for low-grade malignant and benign tumors located in pancreatic body and tail, since it preserves the immune function of the spleen. The splenic-vessel-preserving (SVP) Kimura technique and splenic vessel resection Warshaw technique are the two primary procedures.
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