The composition of Ringer solution, a crystalloid fluid that is often used in anaesthesia and intensive care, varies depending on the manufacturer. The knowledge of the actual content in electrolytes and of the characteristics of this fluid is necessary before it is used. We call attention to a certain Ringer solution (Ringer Maco Pharma, Maco Pharma), for which the manufacturer's information about the tonicity and the osmolarity was incorrect. Contrary to what is written on the bag and in the product description (isotonicity, osmolarity of 276.8 mOsm/l), the theoretical osmolarity was 221.4 mOsm/l and the measured osmolality was about 208 mmol/kg, exposing the hypotonic characteristics of this fluid. The use of this product is potentially dangerous in patients with pathologies where the infusion of free water is especially badly supported.
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http://dx.doi.org/10.1016/j.annfar.2005.03.038 | DOI Listing |
Wideochir Inne Tech Maloinwazyjne
October 2024
Department of Emergency, Taizhou Central Hospital, Affiliated Hospital of Taizhou University, Taizhou Zhejiang, China.
Introduction: Fluid resuscitation is the primary sepsis management strategy aimed at reducing mortality and achieving better treatment outcomes in critically hypotensive patients. Still, there are significant ambiguities regarding the most suitable fluid type that would ensure optimization of patient outcomes.
Aim: The aim of this systematic review and meta-analysis was to assess the clinical effectiveness of different resuscitation fluids for sepsis management in critically hypotensive patients.
Ultramicroscopy
February 2025
Australian Centre for Microscopy & Microanalysis, and School of Aerospace, Mechanical and Mechatronic Engineering, The University of Sydney, Sydney, NSW 2006, Australia. Electronic address:
Atom probe tomography (APT) is routinely used to investigate nano-scale solute architecture within multicomponent systems. However, there is no consensus on how to best quantify solute clustering within APT data. This contribution leverages recent developments in the field of non-parametric hypothesis testing of nearest-neighbour distributions to address this critical gap.
View Article and Find Full Text PDFJ Am Assoc Lab Anim Sci
January 2025
Unnecessary and excessive fluid therapy increases the risk of adverse effects such as pulmonary edema. To prevent this, a mini-fluid challenge (MFC) has been utilized to predict whether fluid therapy will improve circulatory dynamics in human intensive care medicine. The study described here investigated whether MFC is also efficacious in pigs.
View Article and Find Full Text PDFEur J Obstet Gynecol Reprod Biol
April 2025
Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA. Electronic address:
Purpose: Since discovering that intravenous (IV) fluid infusion rate of 250 mL/hr during labor decreases incidence of cesarean delivery and decreases time in labor when compared to infusion rate of 125 mL/hr, patients and midwives have expressed concern that increased fluid rates may lead to increased birth weights. Thus, our objectives were to determine the impact, if any, of increased IV fluid infusion rates on birth weight.
Methods: This was a meta-analysis of all randomized controlled trials (RCTs) of low-risk, nulliparous women with gestations ≥ 36 weeks comparing IV fluid rates of 125 vs.
Vet Anaesth Analg
February 2025
Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA, USA.
An 11-year-old, 8 kg, castrated male dog was presented for adrenalectomy, after being diagnosed with pheochromocytoma by identification of elevated urine metanephrines. Phenoxybenzamine was started 1 month before surgery (2 mg kg, twice daily, orally). Anesthetic premedication was performed with methadone (0.
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