The detection of groups of parallel lines is important in applications such as form processing and text (handwriting) extraction from rule lined paper. These tasks can be very challenging in degraded documents where the lines are severely broken. In this paper, we propose a novel model-based method which incorporates high-level context to detect these lines. After preprocessing (such as skew correction and text filtering), we use trained Hidden Markov Models (HMM) to locate the optimal positions of all lines simultaneously on the horizontal or vertical projection profiles, based on the Viterbi decoding. The algorithm is trainable so it can be easily adapted to different application scenarios. The experiments conducted on known form processing and rule line detection show our method is robust, and achieves better results than other widely used line detection methods.
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http://dx.doi.org/10.1109/TPAMI.2005.89 | DOI Listing |
J Am Chem Soc
January 2025
Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, United States.
Spore germination in is initiated by a cascade of activities of several proteins that culminates in the activation of SleC, a cell-wall-processing enzyme. We report herein the details of the enzymatic activities of SleC by the use of synthetic peptidoglycan fragments and of spore sacculi. The reactions include the formation of 1,6-anhydromuramate─a hallmark of lytic transglycosylase activity─as well as a muramate hydrolytic product, both of which proceed through the same transient oxocarbenium species.
View Article and Find Full Text PDFScience
January 2025
Redox and Metalloprotein Research Group, Max Planck Institute of Biophysics, Frankfurt am Main, Germany.
In the ancient microbial Wood-Ljungdahl pathway, carbon dioxide (CO) is fixed in a multistep process that ends with acetyl-coenzyme A (acetyl-CoA) synthesis at the bifunctional carbon monoxide dehydrogenase/acetyl-CoA synthase complex (CODH/ACS). In this work, we present structural snapshots of the CODH/ACS from the gas-converting acetogen , characterizing the molecular choreography of the overall reaction, including electron transfer to the CODH for CO reduction, methyl transfer from the corrinoid iron-sulfur protein (CoFeSP) partner to the ACS active site, and acetyl-CoA production. Unlike CODH, the multidomain ACS undergoes large conformational changes to form an internal connection to the CODH active site, accommodate the CoFeSP for methyl transfer, and protect the reaction intermediates.
View Article and Find Full Text PDFPLoS One
January 2025
Faculty of Geography, University of Bucharest, Bucharest, Romania.
The border line between Bulgaria and Romania was established a century ago on the Danube River's thalweg, going around islands. Over time, islands migrated; to avoid conflicts, islands located on the border line are declared neutral territory by both countries and they exit from use. In this context, the paper aims to draw conclusions on the spatial dynamics of the Danube River's sandy islands along the Bulgaria-Romania border.
View Article and Find Full Text PDFCell Rep
January 2025
Yale Cardiovascular Research Center, Department of Internal Medicine, Section of Cardiology, Yale University School of Medicine, New Haven, CT 06511, USA; Department of Genetics, Yale University School of Medicine, New Haven, CT 06510, USA. Electronic address:
The subcellular localization of mRNAs plays a pivotal role in biological processes, including cell migration. For instance, β-actin mRNA and its associated RNA-binding protein (RBP), ZBP1/IGF2BP1, are recruited to focal adhesions (FAs) to support localized β-actin synthesis, crucial for cell migration. However, whether other mRNAs and RBPs also localize at FAs remains unclear.
View Article and Find Full Text PDFAdv Biotechnol (Singap)
March 2024
Guangdong Provincial Key Laboratory of Pharmaceutical Functional Genes, MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-Sen University, GuangZhou, GuangDong, China.
Biomolecular condensates, also referred to as membrane-less organelles, function as fundamental organizational units within cells. These structures primarily form through liquid-liquid phase separation, a process in which proteins and nucleic acids segregate from the surrounding milieu to assemble into micron-scale structures. By concentrating functionally related proteins and nucleic acids, these biomolecular condensates regulate a myriad of essential cellular processes.
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