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Mycobacterium tuberculosis infection in pregnancy: A systematic review.
PLOS Glob Public Health
November 2024
Department of Infectious Diseases, The University of Melbourne, At the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia.
Article Synopsis
- * Researchers reviewed 47 studies and found that pregnant women have a higher risk of progression to active TB compared to non-pregnant women, with increased risk during pregnancy and after childbirth.
- * The findings suggest that the perinatal period is a key time for screening and preventative treatment, emphasizing the safety and effectiveness of TB preventive treatment (TPT) while calling for further research to improve screening strategies and support informed decision-making among pregnant women.
Latent Tuberculosis Infection Management in Solid Organ Transplantation Recipients: A National Snapshot.
Thorac Res Pract
May 2024
Department of Infectious Diseases and Clinical Microbiology, Mersin University Faculty of Medicine, Mersin, Turkey.
Article Synopsis
- Latent tuberculosis infection (LTBI) screening is essential for solid organ transplant (SOT) recipients, but many centers in Turkey are not adequately performing these screenings.
- In a study involving 766 SOT patients, 46.9% tested positive for LTBI, but only about half of those treated were registered, and there was a low completion rate of treatment.
- The findings highlight the need for better TB risk assessment and adherence to national guidelines to improve pre-transplant care for SOT recipients in Turkey.
Effectiveness of preventive treatment among different age groups and Mycobacterium tuberculosis infection status: a systematic review and individual-participant data meta-analysis of contact tracing studies.
Lancet Respir Med
August 2024
German Center for Infection Research, Partner Site Hamburg-Lübeck-Borstel-Riems, Borstel, Germany; Global TB and Immigrant Health Program, Baylor College of Medicine and Texas Children's Hospital, Houston, TX, USA; Division of Clinical Infectious Diseases, Research Center Borstel, Borstel, Germany.
Background: Tuberculosis is a preventable disease. However, there is debate regarding which individuals would benefit most from tuberculosis preventive treatment and whether these benefits vary in settings with a high burden and low burden of tuberculosis. We aimed to compare the effectiveness of tuberculosis preventive treatment in exposed individuals of differing ages and Mycobacterium tuberculosis infection status while considering tuberculosis burden of the settings.
View Article and Find Full Text PDFHigh-dose, short-duration versus standard rifampicin for tuberculosis preventive treatment: a partially blinded, three-arm, non-inferiority, randomised, controlled trial.
Lancet Respir Med
June 2024
Montreal Chest Institute, Research Institute of the McGill University Health Center, Montreal, QC, Canada; McGill International TB Centre, McGill University, Montreal, QC, Canada. Electronic address:
Background: Tuberculosis preventive treatment (TPT) is a key component of tuberculosis elimination. To improve completion and reduce the burden for people and health systems, short, safe, and effective TPT regimens are needed. We aimed to compare safety and treatment completion of various doses and durations of rifampicin in people who were recommended to receive TPT.
View Article and Find Full Text PDFPrevalence estimates of tuberculosis infection in adults in Denmark: a retrospective nationwide register-based cross-sectional study, 2010 to 2018.
Euro Surveill
March 2024
Department of Infectious Diseases and Mycobacterial Centre for Research Southern Denmark, MyCRESD, Odense University Hospital, Denmark.
BackgroundTuberculosis (TB) elimination requires identifying and treating persons with TB infection (TBI).AimWe estimate the prevalence of positive interferon gamma release assay (IGRA) tests (including TB) and TBI (excluding TB) in Denmark based on TBI screening data from patients with inflammatory bowel disease (IBD) or inflammatory rheumatic disease (IRD).MethodsUsing nationwide Danish registries, we included all patients with IBD or IRD with an IGRA test performed between 2010 and 2018.
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