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In-silico simultaneous respiratory and circulatory measurement during voluntary breathing, exercise, and mental stress: A computational approach.
PLoS Comput Biol
December 2024
Human Science Research-Domain, Toyota Central R&D Labs., Inc., Nagakute, Japan.
Voluntary breathing (VB), short-term exercise (STE), and mental stress (MS) can modulate breathing rate (BR), heart rate (HR), and blood pressure (BP), thereby affecting human physical and mental state. While existing experimental studies have explored the relationship between VB, STE, or MS and BR, HR, and BP changes, their findings remain fragmented due to individual differences and challenges in simultaneous, BR, HR, and BP measurements. We propose a computational approach for in-silico simultaneous measurements of the physiological values by comprehensive prediction of the respiratory and circulatory system responses to VB, STE, or MS.
View Article and Find Full Text PDFEmpirical Testing of a Middle-Range Theory for Ineffective Breathing Pattern in Children With Congenital Heart Disease.
J Clin Nurs
November 2024
Regional University of Cariri, Crato, Ceará, Brazil.
Aim: To test a middle-range theory (MRT) for the nursing diagnosis of ineffective breathing pattern in children with congenital heart disease (CHD) based on analysis of two general propositions.
Methods: This cross-sectional study is guided by STROBE. The propositions represent hypotheses about the relationships between the concepts of this MRT to be tested empirically, and thus, log-linear models were used to verify the structure of the proposition related to the stimuli.
Hyperpolarized 129Xe Lung MRI and Spectroscopy in Mechanically Ventilated Mice.
J Vis Exp
October 2024
Center for Pulmonary Imaging Research, Division of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center; Department of Biomedical Engineering, University of Cincinnati; Imaging Research Center, Department of Radiology, Cincinnati Children's Hospital Medical Center; Department of Pediatrics, University of Cincinnati; Division of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center;
Article Synopsis
- Hyperpolarized xenon-129 (Xe) is a specialized MRI contrast agent that helps measure various aspects of lung function, making it useful for diagnosing and tracking lung diseases in humans.
- It is approved for clinical use in places like the U.S. and U.K. and offers noninvasive ways to study lung health in preclinical research settings, particularly with mice, which are commonly used in genetic studies.
- The text outlines practical procedures and checklists for effectively using Xe MRI in animal studies, focusing on ensuring accurate data collection related to lung disease monitoring.
Design and Implementation of a Computer-Controlled Hybrid Oscillatory Ventilator.
J Med Device
March 2025
Departments of Anesthesia, Radiology Roy J. Carver Department of Biomedical Engineering, University of Iowa, 200 Hawkins Dr, Iowa City, IA 52242.
During mechanical ventilation, lung function and gas exchange in structurally heterogeneous lungs may be improved when volume oscillations at the airway opening are applied at multiple frequencies simultaneously, a technique referred to as multifrequency oscillatory ventilation (MFOV). This is in contrast to conventional high-frequency oscillatory ventilation (HFOV), for which oscillatory volumes are applied at a single frequency. In the present study, as a means of fully realizing the potential of MFOV, we designed and tested a computer-controlled hybrid oscillatory ventilator capable of generating the flows, tidal volumes, and airway pressures required for MFOV, HFOV, conventional mechanical ventilation (CMV), as well as oscillometric measurements of respiratory impedance.
View Article and Find Full Text PDFQuantitative assessment of chlorine gas inhalation injury based on endoscopic OCT and spectral encoded interferometric microscope imaging with deep learning.
APL Photonics
September 2024
Department of Biomedical Engineering, Ulsan National Institute of Science and Technology (UNIST), Ulsan 44919, Republic of Korea.
Article Synopsis
- Chlorine exposure leads to serious airway injuries, but the long-term structural effects aren't fully understood; researchers used a high-tech imaging system to study these effects using rabbits as models.
- The study involved exposing rabbits to high levels of chlorine gas and then utilizing advanced imaging techniques to monitor changes in their airway structures, particularly focusing on sloughing (the shedding of the airway surface) and cilia function.
- Results indicated that airway sloughing peaked 30 minutes post-exposure and that cilia movement was negatively impacted, suggesting this approach could improve diagnosis and treatment evaluation for gas inhalation injuries.
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