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A model of oral mucosal carcinogenesis using the water-soluble carcinogen 4-nitroquinoline-1-oxide (4NQO) was combined with a model of oral mucosal candidosis to examine the ability of Candida albicans to promote the development of neoplasia in suitably initiated epithelium. Sprague-Dawley rats were initiated by the application of 4NQO to their palatal and tongue mucosa 3 times weekly for 4 weeks. The animals then received either application of a phorbol ester to act as a promoter, induction of experimental oral mucosal infection with C. albicans, or no further procedures. Animals were killed at 34 or 52 weeks and the tongues and palates sectioned for light-microscopic examination. Control groups with no treatment, mucosal infection only, phorbol ester application only, 4NQO with the tetracycline or vehicle application only were also used. The development of carcinoma in the experimental groups was similar to that in the positive control groups, indicating that the particular strain of Candida used had a similar ability to promote neoplastic changes as the known promoter phorbol-12,13-didecanoate and caused neoplastic changes to occur by week 34 with no additional lesions occurring by week 52. This indicated that the speculation that strains of C. albicans may participate in causing neoplastic transformation in humans was well founded.
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http://dx.doi.org/10.1093/carcin/13.5.783 | DOI Listing |
BMC Oral Health
March 2025
College of Dental Medicine, QU Health, Qatar University, Doha, Qatar.
Background: The literature is scarce and inconsistent regarding the prevalence, types, and risk factors of oral pigmented lesions (OPL). The present study investigated the prevalence, types, and distribution of OPL, as well as their associated factors among Yemeni dental patients.
Methods: This cross-sectional study was conducted among 1920 dental patients attending the dental clinics, Sanaa University, Yemen over a period of 10 months (from March to December 2021).
J Ethnopharmacol
March 2025
Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, The MOE Laboratory of Standardization of Chinese Medicines, Shanghai R&D Center for Standardization of Chinese Medicines, 1200 Cailun Road, 201203, China. Electronic address:
Ethnopharmacological Relevance: Zuojin Pill (ZJP) is a traditional Chinese medicine (TCM) formula composed of Coptidis Rhizoma and Euodiae Fructus in a ratio of 6:1 (w/w), which has been widely used for treating gastrointestinal disorders, especially stomach heat syndrome (SHS). However, the active alkaloids in ZJP showed low plasma exposure in rats following oral administration, which failed to explain their potent pharmacological effects, thereby limiting further mechanism studies.
Aim Of The Study: This study aimed to investigate the in vivo exposure and tissue distribution propensities of the active alkaloids in normal and SHS rats following oral administration of ZJP.
Clin Oral Investig
March 2025
Department of Medical Biology, Faculty of Medicine, Ege University, İzmir, Turkey.
Objective: This study aims to investigate the cytotoxic, apoptotic, and genotoxic effects of eleven mouthwashes, which are hypothesized to pose potential toxic risks to oral mucosal tissues, through in-vitro experiments using human gingival fibroblast(hGF) cell cultures and to compare the antibacterial efficacy of these mouthwashes.
Materials And Methods: Healthy hGF cell lines were derived from individuals under ethical standards. The cytotoxic effects of the mouthwashes (Colgate 2in1,Colgate Optic White, Colgate Plax, Curasept, Elmex, Kloroben, Listerine Cool Mint, Listerine Zero, Meridol, Oral-B Pro Expert, Sensodyne Pronamel) were assessed in real-time using the xCELLigence system, which monitored cellular activity at 5-minute intervals over 72 h.
SLAS Technol
March 2025
Department of Periodontics & Oral Mucosal Diseases, The Affiliated Stomatology Hospital, Southwest Medical University, Luzhou 646000, Sichuan, China; Luzhou Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Luzhou 646000, Sichuan, China; Institute of Stomatology, Southwest Medical University, Luzhou 646000, Sichuan, China. Electronic address:
Background: Almost 90% of head and neck malignancies are malignant squamous cell cancers, making it the sixth most common malignancy in the developing countries, with an overall five-year overall survival rate about 40%-50%. Early diagnosis and treatment can bring a better prognosis. Fibroblast growth factor (FGF) is an important polypeptide in vivo.
View Article and Find Full Text PDFSci Adv
March 2025
Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX, USA.
Obeldesivir (ODV; GS-5245) is an orally administered ester prodrug of the parent nucleoside GS-441524 that has broad spectrum antiviral activity inhibiting viral RNA-dependent RNA polymerases. We recently showed that ODV completely protects cynomolgus macaques against lethal infection with Sudan virus when given 24 hours after parenteral exposure. Here, we report that once daily oral ODV treatment of cynomolgus and rhesus macaques for 10 days confers 80 and 100% protection, respectively, against lethal Ebola virus infection when treatment is initiated 24 hours after mucosal (conjunctival) exposure.
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