Carbon-13 NMR spectra of the stable polymorphs of solid bambuterol hydrochloride (BHC) and terbutaline sulfate (TBS) are reported and the resonances assigned with the aid of solution-state spectra. A protocol is presented for quantification of BHC in a formulation in lactose, together with TBS, relative to a reference peak from magnesium stearate. This protocol compares the intensity of an aromatic signal of BHC with that of the main-chain methylene carbons of the stearate. It is shown that the limit of detection (LOD) of BHC in this system under the conditions described is 0.5% with an effective limit of quantification (LOQ) of 1.0%. A calibration plot for the quantification is presented and the various factors affecting the accuracy of the measurements are described. No discernible differences are found in the spectra of physical mixtures of the components, whole tablets, and crushed or ground tablets.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jpba.2005.01.052 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Determination of 13 potential anti-obesity agents in hair by dispersive liquid-liquid microextraction-assisted UHPLC-MS/MS.
J Pharm Biomed Anal
August 2024
School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China; Key Laboratory of Drug Quality Control and Pharmacovigilance (China Pharmaceutical University), Ministry of Education, Nanjing 210009, China; NMPA Key Laboratory for Research and Evaluation of Pharmaceutical Preparations and Excipients, Nanjing 210009, China. Electronic address:
As the adulteration of dietary supplements with synthetic drugs remains a prevalent issue, the inclusion of anti-obesity agents may pose health risks, potentially leading to central nervous system or cardiovascular diseases. However, surveillance studies on the use of anti-obesity agents by the Chinese population are limited. This study aims to establish an efficient and rapid hair pretreatment method using dispersive liquid-liquid microextraction (DLLME) combined with high-speed grinding and develop a sensitive and accurate analytical method employing ultra high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) for detecting 13 potential anti-obesity agents in hair samples.
View Article and Find Full Text PDFStability indicating eco-friendly quantitation of terbutaline and its pro-drug bambuterol using quantitative proton nuclear magnetic spectroscopy.
BMC Chem
January 2024
Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt.
Article Synopsis
- The study focuses on using quantitative H-NMR spectroscopy to analyze the bronchodilator drug terbutaline sulfate and its pro-drug bambuterol hydrochloride in both pure forms and pharmaceutical preparations.* -
- The method involved using deuterium oxide as a solvent and phloroglucinol anhydrous as an internal standard, with specific signal peaks at 6.3 ppm for terbutaline and 2.9 ppm for bambuterol used for quantification.* -
- The developed method has been validated for accuracy and reliability, meets international standards, and exhibits a "green" profile, allowing assaying of both drugs individually and together, indicating its ability to assess stability.*
Rivastigmine-Bambuterol Hybrids as Selective Butyrylcholinesterase Inhibitors.
Molecules
December 2023
Post-Doctoral Innovation Site, Jinan University Affiliation, Yuanzhi Health-Tech Inc., Hengqin District, Zhuhai 519000, China.
Selective butyrylcholinesterase inhibitors are considered promising drug candidates for the treatment of Alzheimer's disease. In this work, one rivastigmine-bambuterol hybrid (MTR-1) and fourteen of its analogues were synthesized, purified, and characterized. In vitro cholinesterase assays showed that all the compounds were more potent inhibitors of BChE when compared to AChE.
View Article and Find Full Text PDF[Determination of 14 -agonists in animal meat by ultra high performance liquid chromatography-tandem mass spectrometry].
Se Pu
December 2023
Tangshan Agricultural Products Quality and Safety Inspection and Testing Center, Tangshan Food and Drug Comprehensive Inspection and Testing Center, Tangshan 063000, China.
The addition of -agonists to animal feed can significantly improve the lean-meat rate of pigs, cattle, sheep, and other animals. However, the food residues of -agonists are harmful to human health. When meat with -agonist residues is consumed, poisoning symptoms such as palpitation, dizziness, and muscle tremors may develop, and damage to the cardiovascular system, liver, and kidney may occur.
View Article and Find Full Text PDFApplication of wastewater-based epidemiology to estimate the usage of beta-agonists in 31 cities in China.
Sci Total Environ
October 2023
School of Pharmacy, China Pharmaceutical University, No. 24 Tongjiaxiang Road, Nanjing, 210009, China; China National Narcotics Control Commission, China Pharmaceutical University Joint Laboratory on Key Technologies of Narcotics Control, No. 24 Tongjiaxiang Road, Nanjing, 210009, China; Key Laboratory of Drug Quality Control and Pharmacovigilance, China Pharmaceutical University, Ministry of Education, No. 639 Longmian Avenue, Nanjing, 211100, China. Electronic address:
The illegal use of beta-agonists could cause severe problems to human health. In this study, the usage of beta-agonists in 31 cities across China was estimated using wastewater-based epidemiology (WBE). The proposed method is based on solid-phase extraction (SPE) and LC-MS/MS and was developed and validated to determine the concentration of seven beta-agonists in wastewater.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!