Liberia's prolonged post-conflict transition has negatively impacted its health infrastructure, including the functioning of its health care delivery system. Considering the current national health crises, a study was conducted to identify research gaps and the need to propose changes for improving the health care delivery system in the country. The study results clearly demonstrated a lack of HIV/AIDS research infrastructure including organizational structure, linkages, leadership, champions, expertise, resources, and policies and procedures. Alignment of research needs and practice, and research use to support HIV/AIDS service delivery programmes in the country was also limited. An international research capacity-building partnership is proposed as an effective planned change strategy to strengthen HIV/AIDS-related research infrastructure and to inform management and practice within the Liberian HIV/AIDS service delivery system. A proposed capacity-building planning model can also strengthen research infrastructure and the production and use of research to positively impact the HIV/AIDS epidemic in Liberia and other developing countries.
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http://dx.doi.org/10.1111/j.1365-2753.2005.00532.x | DOI Listing |
BMC Health Serv Res
January 2025
Department of Health Services Research, Peter MacCallum Cancer Centre, Melbourne, Australia.
Background: The provision of healthcare is complex. When evidence-practice gaps are identified, interventions to improve practice across multi-level systems are required. These interventions often consist of multiple interacting components and behaviours.
View Article and Find Full Text PDFDiscov Oncol
January 2025
Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, 200349, Craiova, Romania.
Cancer remains the second leading cause of death globally, driving the need for innovative therapies. Among natural compounds, maytansinoids have shown significant promise, contributing to nearly 25% of recently approved anticancer drugs. Despite their potential, early clinical trials faced challenges due to severe side effects, prompting advancements in delivery systems such as antibody-maytansinoid conjugates (AMCs).
View Article and Find Full Text PDFCommun Med (Lond)
January 2025
Biomedical and Mobile Health Technology Research Lab, ETH Zürich, Zürich, Switzerland.
Background: Increasing demands, such as the COVID-19 pandemic, have presented substantial challenges to global healthcare systems, resulting in staff shortages and overcrowded emergency rooms. Health kiosks have emerged as a promising solution to improve overall efficiency and healthcare accessibility. However, although kiosks are commonly used worldwide for access to information and financial services, the health kiosk industry, valued at $800 million, accounts for just 1.
View Article and Find Full Text PDFNat Commun
January 2025
School of Pharmaceutical Sciences, MOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Tsinghua University, Beijing, P.R. China.
Targeted protein delivery with nanocarriers holds significant potential to enhance therapeutic outcomes by precisely directing proteins to specific organs or tissues. However, the complex interactions between nanocarriers and the biological environment pose considerable challenges in designing effective targeted delivery vehicles. In this study, we address this challenge by leveraging DNA-barcoded high-throughput screening.
View Article and Find Full Text PDFSci Rep
January 2025
Department of Management Information Systems, Faculty of Economics and Administration, King Abdulaziz University, Jeddah, Saudi Arabia.
In the current era, IoT-based healthcare solutions play a pivotal role in transforming the healthcare landscape by addressing key challenges and significantly enhancing the quality, accessibility, and efficiency of medical services, particularly for individuals in remote areas. This paper introduces innovative operations on fractional fuzzy sets (FFS), specifically the Hamacher sum and product, and establishes corresponding operational laws. Building upon these foundations, we propose novel aggregation operators (AoPs) leveraging Hamacher norms and rigorously analyze their properties within the FFS framework.
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