Ceftriaxone is known to induce reversible precipitates in the gallbladders of adults and children. However, ceftriaxone-associated gallbladder pseudolithiasis in children is rarely reported in Taiwan. We report a case of 5-year-old boy with Salmonella gastroenteritis, who was treated with ceftriaxone due to multidrug resistance and severe course. Cholelithiasis developed five days after initiation of ceftriaxone therapy and completely resolved one month after the end of treatment. Pediatricians and radiologists must be aware of this complication to prevent anxiety and unnecessary cholecystectomy.
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Jpn J Radiol
March 2024
Department of Radiology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan.
Obtaining an imaging diagnosis of various hepatobiliary and pancreatic disorders caused by certain drugs can often be challenging. Familiarity with these conditions may improve diagnostic accuracy and patient management. This review aimed to describe the imaging findings of drug-associated hepatobiliary and pancreatic disorders and identify suggestions for obtaining a correct diagnosis.
View Article and Find Full Text PDFJ Infect Chemother
August 2023
Hematology, Graduate School of Medicine, Osaka Metropolitan University, Japan.
We herein report a 76-year-old man with acquired hemophilia A (AHA) who developed gallbladder rupture due to Ceftriaxone (CTRX)-associated pseudolithiasis. The patient was admitted for an examination of systemic subcutaneous bleeding. A blood test showed a prolonged activated partial thromboplastin time and sequentially revealed low factor VIII activity (<1%) and a high factor VIII inhibitor level of 143 BU/mL.
View Article and Find Full Text PDFDigestion
August 2023
Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan.
Introduction: Ceftriaxone (CTRX) is known to occasionally cause pseudolithiasis. This condition is often observed in children; however, few studies have reported the incidence and risk factors for CTRX-associated pseudolithiasis.
Methods: In this single-center retrospective study, we investigated the incidence of and risk factors for CTRX-associated pseudolithiasis in adults.
Intern Med
December 2021
Department of Gastroenterology, Graduate School of Medicine, Osaka City University, Japan.
Objective Ceftriaxone (CTRX) is a widely used antibiotic because of its long plasma half-life and good tissue transmission. Many of the reported studies on CTRX-associated pseudolithiasis were performed in children. Although some studies have been published in adults, there are no studies limited to elderly people.
View Article and Find Full Text PDFIntern Med
November 2020
Department of Gastroenterology, Dokkyo Medical University, Japan.
A 78-year-old man had been undergoing treatment with Cefamezin for pyogenic spondylitis. Because of complication of a urinary tract infection, the medication was switched to ceftriaxone (CTRX) 2 g/day. On day 18 after starting CTRX, the patient began experiencing abdominal pain.
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