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Statistical methods to adjust for the effects on intervention compliance in randomized clinical trials where precision treatment rules are being developed.
Int J Methods Psychiatr Res
March 2025
Department of Health Care Policy, Harvard Medical School, Boston, Massachusetts, USA.
Background: Heterogeneity of treatment effects (HTEs) can occur because of either differential treatment compliance or differential treatment effectiveness. This distinction is important, as it has action implications, but it is unclear how to distinguish these two possibilities statistically in precision treatment analysis given that compliance is not observed until after randomization. We review available statistical methods and illustrate a recommended method in secondary analysis in a trial focused on HTE.
View Article and Find Full Text PDFTrajectories of Change, Illness Understanding, and Parental Worries in Children and Adolescents Undergoing Internet-Delivered Cognitive-Behavioral Therapy for Functional Abdominal Pain Disorders: Protocol for a Single-Case Design and Explorative Pilot Study.
JMIR Res Protoc
January 2025
Department of Child and Adolescent Psychiatry, Aarhus University Hospital, Aarhus N, Denmark.
Background: Functional abdominal pain disorders (FAPDs) are common in young people and are characterized by persistent or recurrent abdominal symptoms without apparent structural or biochemical abnormalities. FAPDs are associated with diminished quality of life, school absence, increased health care use, and comorbid anxiety and depression. Exposure-based internet-delivered cognitive behavioral therapy (ICBT) has demonstrated efficacy in alleviating abdominal symptoms and improving quality of life.
View Article and Find Full Text PDFInternet-delivered cognitive behaviour therapy for university students: Preference trial for various course durations.
Internet Interv
March 2025
Department of Psychology, University of Regina, 3737 Wascana Parkway, Regina, SK S4S 0A2, Canada.
Background: Internet-delivered cognitive behaviour therapy (ICBT) is an accessible and effective treatment option for post-secondary students, but engagement and completion rates are less favourable than in non-student populations in routine care. Studies on students' treatment preferences suggest that a range of options should be offered. Examining students' engagement and outcomes associated with ICBT course options of varying durations can help inform how to optimally deliver ICBT to university students in routine care.
View Article and Find Full Text PDFTailored internet-delivered cognitive behavior therapy for depression in older adults: a randomized controlled trial.
BMC Geriatr
December 2024
Department of Psychiatry in Linköping, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
Background: Depression is a common and serious problem in older adults, but few have access to psychological treatments. Internet-delivered Cognitive Behavioral Therapy (ICBT) has the potential to improve access and has been found to be effective in adults with depression. The aim of this study was to examine the effects of tailored ICBT for depression in older adults aged 65 years or older.
View Article and Find Full Text PDFCombining internet-delivered cognitive behavioural therapy and attention bias modification for reducing depressive symptoms in firefighters: a randomized controlled trial.
Behav Cogn Psychother
November 2024
Kungming Training Corps of National Fire and Rescue Administration, Kunming, China.
Article Synopsis
- Firefighters face high rates of depression due to trauma and stress in their jobs, prompting a study to assess new treatment methods.
- The study tested an 8-week program combining internet-delivered cognitive behavioral therapy (iCBT) and attention bias modification (ABM) on 138 active firefighters in Kunming, China.
- Results showed that this combined approach significantly reduced depressive symptoms compared to a control group, although it did not significantly change attention bias, suggesting potential benefits of the intervention for mental health in emergency responders.
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