This multicenter retrospective chart review study performed on 162 cryptorchid patients and on 34 subjects with retractile testes suggests that cryptorchidism and retractile testes can alter spermatogenesis, with more serious damage observed in bilateral cryptorchidism. This spermatogenetic impairment is probably related to the lack of an appropriate or timely surgical correction.
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Pre-referral ultrasound for cryptorchidism: Still common, still not necessary.
J Paediatr Child Health
December 2024
Department of Paediatric Surgery, Queensland Children's Hospital, Brisbane, Queensland, Australia.
Aim: Evidence-based guidelines do not recommend imaging in cryptorchidism, but anecdotally most referrals include an ultrasound report. We aimed to assess the frequency, utility and burden of imaging in children referred with presumptive disorders of testicular descent, and to assess trends over a 7-year period before and after local and international guidelines have been introduced.
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Role of genetic variations and protein expression of β-Microsemino protein in intrauterine insemination outcome of unexplained infertile men: A case-control study.
Int J Reprod Biomed
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Department of Genetics, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.
Background: Intrauterine insemination (IUI) is often the first-line treatment for unexplained infertility. -Microsemino protein (MSMB) is an abundant protein in seminal plasma that has an inhibitory effect on spontaneous acrosome reaction.
Objective: The present study aimed to evaluate gene variations and protein expression on IUI success rate in unexplained infertile men.
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Adv Pediatr
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David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Undescended testis is the most common genital disorder identified at birth. Boys who do not have spontaneous descent of the testis at 6 months of age, adjusted for gestational age, should be referred to pediatric urology for timely orchiopexy. Retractile testes are at risk for secondary ascent of the testes and should be monitored by physical examination annually.
View Article and Find Full Text PDFUse of Ultrasound in the Evaluation of Cryptorchidism: A Single-Institution Analysis.
J Surg Res
July 2024
Department of Surgery, Children's Mercy, Kansas City, Missouri. Electronic address:
Introduction: The American Urological Association guidelines recommend against the performance of ultrasound and other imaging modalities in the evaluation of patients with cryptorchidism before expert consultation. We aimed to examine our institutional experience with cryptorchidism and measure adherence to currently available guidelines.
Methods: An institutional review board-approved retrospective review of ultrasound utilization in the evaluation of patients with cryptorchidism was performed from June 1, 2016, to June 30, 2019, at a single tertiary level pediatric hospital.
Surgical treatment of cryptorchidism: current insights and future directions.
Front Endocrinol (Lausanne)
March 2024
New Children's Hospital, Department of Pediatric Surgery, Section of Pediatric Urology, Helsinki University Hospital, Helsinki, Finland.
Cryptorchidism presents with an incidence of 1-5% with potential long-term implications on future fertility and overall health. This review focuses on surgical treatment modalities, their impact on testicular development, and function while addressing the Nordic consensus statement as well as current European Association of Urology (EAU) and American Urological Association (AUA) guidelines. Congenital and acquired cryptorchidism present distinctive challenges in surgical management, with different implications for fertility.
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