Wnt/beta-catenin--a canonical tale of cell-fate choice in the vertebrate skeleton.
Dev Cell
Department of Oral and Developmental Biology, Harvard School of Dental Medicine, Boston, MA 02115, USA.
Published: May 2005
Three exciting papers in this issue of Developmental Cell provide new insights into the regulation of chondrocytic, osteoblastic, and osteoclastic differentiation during skeletal development and postnatal growth. The studies demonstrate that Wnt/beta-catenin signaling represents both a mechanism in mesenchymal precursor cells for selecting between chondrocytic and osteoblastic fates as well as a mechanism in osteoblasts for stimulating the production of an inhibitor of osteoclast formation.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.devcel.2005.04.008 | DOI Listing |
Similar Publications
Mechanobiological Model of Endochondral Ossification and Trabecular Bone Modeling.
Int J Numer Method Biomed Eng
March 2025
Universidad Nacional de Colombia, Engineering Modeling and Numerical Methods Group (GNUM) & Instituto de Biotecnología, Bogotá, Colombia.
This work presents the integration of mechanobiological models to predict the natural evolution of bone modeling and remodeling processes to obtain the architecture of trabecular bone from the embryonic stage in mammalians. Bone modeling is simulated in two and three dimensions using a reaction-diffusion mechanism with parameters in Turing space. This approach involves the interaction of two molecular factors (VEGF and MMP13) released by hypertrophic chondrocytes that diffuse and interact within a hyaline cartilage matrix.
View Article and Find Full Text PDFThrombospondin 1 Promotes Cytoskeleton Remodeling, Dedifferentiation, and Pulmonary Metastasis through ITGA1 and ITGA6 in Osteosarcoma.
Int J Biol Sci
March 2025
Department of Orthopedic Surgery, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, PR China.
Dedifferentiation of osteosarcoma cells leads to poor prognosis. We plan to identify the key molecules that are involved in cell dedifferentiation and explore how they promote the pulmonary metastasis of osteosarcoma cells. We performed a sphere formation assay and confirmed that the spheroid cells could be redifferentiated into osteoblasts, adipocytes, and chondrocytes in specific medium, and the stem cell-like markers Stro-1 and CD117 were detected on the cell surface, which indicated that the spheroid cells were dedifferentiated cells.
View Article and Find Full Text PDFInsights into the role of histone lysine demethylases in bone homeostasis and skeletal diseases: A review.
Int J Biol Macromol
March 2025
School of Sports Health, Shenyang Sport University, Shenyang, Liaoning, China. Electronic address:
Histone lysine demethylases (KDMs), as important epigenetic regulators, are involved in various biological processes such as energy metabolism, apoptosis, and autophagy. Recent research shows that KDMs activate or silence downstream target genes by removing lysine residues from histone tails, and participate in the regulation of bone marrow mesenchymal stem cells (BM-MSCs), osteoblasts (OB), osteoclasts (OC), chondrocytes and other skeletal cell development, differentiation and formation. Moreover, several members of the KDM family affect the occurrence and development of bone diseases such as osteoporosis (OP), osteoarthritis (OA), osteosarcoma (OS), by regulating target genes.
View Article and Find Full Text PDFMethyltransferase-Like 3-Mediated N-Methyladenosine Modification on RNAs: A Novel Perspective for the Pathogenesis and Treatment of Bone Diseases.
J Cell Mol Med
March 2025
Department of Pediatrics, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Ministry of Education), NHC Key Laboratory of Chronobiology, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China.
Osteoarthritis, osteoporosis, and osteosarcoma are prevalent osseous pathologies associated with the aberrant functionality of chondrocytes, osteoclasts, and osteoblasts, respectively. These conditions frequently exhibit therapeutic resistance and possess a high mortality risk, thus representing substantial health threats. To mitigate these concerns, it is imperative to investigate novel mechanistic insights.
View Article and Find Full Text PDFThe Roles of Forkhead Box O3a (FOXO3a) in Bone and Cartilage Diseases - A Narrative Review.
Drug Des Devel Ther
March 2025
Department of Joint Surgery, Ganzhou People's Hospital, Ganzhou, 341000, People's Republic of China.
Bone and cartilage diseases are significantly associated with musculoskeletal disability. However, no effective drugs are available to cure them. FOXO3a, a member of the FOXO family, has been implicated in cell proliferation, ROS detoxification, autophagy, and apoptosis.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!
© LitMetric 2025. All rights reserved.