AI Article Synopsis
- The study investigates risk factors for distant metastasis in patients with malignant fibrous histiocytoma, focusing on a group of sixty treated individuals.
- Significant factors identified include being older than 70, having insufficient surgical margins, local recurrence, and vascular invasion, with vascular invasion being the most critical risk factor.
- The findings emphasize the importance of early intervention for patients showing signs of vascular invasion to enhance their prognosis.
Article Abstract
Background: The appearance of distant metastasis is a fatal sign in patients with soft tissue sarcoma. Therefore, we studied the risk factors associated with distant metastasis that appear in malignant fibrous histiocytoma.
Materials And Methods: The study group comprised sixty patients treated for malignant fibrous histiocytoma at our hospital between 1991 and 2002. We retrospectively studied whether age, tumor size, tumor site, developmental form, surgical margin, local recurrence, histological subtype, vascular invasion and histological grade are risk factors associated with the appearance of distant metastasis.
Results: A univariate analysis showed that, for those patients older than 70 years of age, insufficient surgical margin, the presence of local recurrence and vascular invasion are significant risk factors associated with the appearance of distant metastasis. A multivariate analysis showed only the presence of vascular invasion to be a significant risk factor as well.
Conclusion: Histological vascular invasion by tumors is a risk factor associated with distant metastasis that appears in malignant fibrous histiocytoma. Taking early measures for patients with vascular invasion is necessary to improve the prognosis.
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