Background: Valuable correlations could be made between serum prostate specific antigen (PSA) and prostate histopathology by the use of autopsy sampling if post-mortem PSA data were informative. However, PSA forms and levels in autopsy sera have not been investigated.
Materials And Methods: Paired ante- and post-mortem sera were collected for a series of cases. Total and free PSA levels in each were determined and compared. These PSA data were correlated with corresponding changes in serum electrolyte levels.
Results: Total PSA levels were similar in ante- and post-mortem sera if autopsy blood was drawn by approximately 24 hours following the time of death. Free PSA levels, however, were increased approximately two-fold in most post-mortem sera analyzed. Increases in the serum electrolytes potassium, magnesium and phosphate correlated positively with increases in free PSA.
Conclusion: Total PSA levels in ante- and post-mortem sera were comparable. Free PSA levels had approximately doubled by autopsy, but may be normalized in relation to increases in serum electrolyte levels. The use of autopsy prostates and PSA data would avoid diagnostic bias from use of clinical material and permit extensive analysis to be carried out, which is not normally feasible with live subjects.
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Ther Adv Musculoskelet Dis
January 2025
The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan, 1-1 Iseigaoka, Yahata-nishi, Kitakyushu 807-8555, Japan.
Psoriatic arthritis (PsA) presents various clinical manifestations, including skin lesions, peripheral arthritis, axial involvement, enthesitis, nail involvement, dactylitis, and uveitis. In addition, it causes a high incidence of lifestyle-related diseases and an increase in cerebrovascular and cardiovascular events. As the pathology of PsA has been clarified, molecular-targeted drugs targeting tumor necrosis factor-α, interleukin (IL)-17A, IL-17A/F, IL-17 receptor, IL-12/23(p40), IL-23p19, Cytotoxic T-lymphocyte Antigen-4 (CTLA-4), Janus kinase, and phosphodiesterase-4 have been developed and are widely used in clinical practice.
View Article and Find Full Text PDFFront Pharmacol
December 2024
Guangzhou ZhiYi Biotechnology Co. Ltd., Guangzhou, China.
() is a Gram-negative, obligate anaerobic, commensal bacterium residing in the human gut and holds therapeutic potential for ulcerative colitis (UC). Previous studies have indicated that capsular polysaccharide A (PSA) of is a crucial component for its effectiveness, possessing various biological activities such as anti-inflammatory, anti-tumor, and immune-modulating effects. We previously isolated and characterized the strain ZY-312 from the feces of a healthy breastfed infant, and extracted its PSA, named TP2.
View Article and Find Full Text PDFArab J Urol
September 2024
Urology Department, Misr University for Science and Technology, 6th of October City, Egypt.
Background And Purpose: Though TURP remains the primary treatment for BPH, advancements in energy and technology have introduced innovative transurethral surgical options. In this study, we assessed and compared the effectiveness and safety of using thulium laser and bipolar for endoscopic enucleation of prostate exceeding 80 g.
Patients And Methods: Between January 2022 and July 2023, this study enrolled patients with LUTS due to BPH and a prostate size of ≥80 g.
Sci Rep
January 2025
Henry Ford Health, Detroit, MI, USA.
Traditional medicine is widely used in sub-Saharan Africa, particularly in Ghana, where it is commonly integrated with modern orthodox medicine. This study examines the barriers that delay the pursuit of orthodox medical care for prostate cancer (PCa) in Ghana's Central region, where a blend of traditional and modern orthodox medicine exists. The preference for indigenous traditional medicine often results in late-stage presentations of PCa, adversely affecting patient outcomes.
View Article and Find Full Text PDFAging Male
December 2025
Department of Urology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Objectives: This study aimed to elucidate the correlation of Visceral Adiposity Index (VAI) with prostate cancer (PCa) among men aged 40 years and older in the United States.
Methods: Analysis included multivariate linear and logistic regression, smoothing curve fitting, and threshold effect evaluation using 2003-2010 National Health and Nutrition Examination Survey (NHANES) data. The stability of this relationship across demographic groups was assessed via subgroup analyses and interaction tests.
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