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Dexamethasone can be used to prevent nausea and vomiting after surgery, but there is concern that it may induced perineal irritation. The aim of this study was to investigate the attenuation effect of dilution and slow injection on dexamethasone-induced perineal irritation. In this prospective, randomized, double-blind study, a total of 400 patients were enrolled and allocated into four groups: Group I, receiving 2 mL dexamethasone (5 mg/mL), Group II, receiving 5 mL dexamethasone (2 mg/mL), Group III, receiving 10 mL dexamethasone (1 mg/mL), and Group IV receiving 20 mL dexamethasone (0.

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Previous studies have found that intravenous dexamethasone may produce perineal pruritus in some patients when administered as premedicant in the preoperative period. This randomized controlled, double-blind study evaluated the efficacy of pretreatment of lidocaine on the incidence and severity of dexamethasone-induced perineal pruritus. 400 patients were enrolled in this study and allocated randomly into four groups (n=100, in each).

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Dexamethasone has been widely used before general anesthesia induction. However, previous studies have found that a pre-induction bolus dose of dexamethasone sometimes causes perineal pruritus. We hypothesized that an appropriate prolongation of the injection time might suppress dexamethasone-induced perineal pruritus.

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