AI Article Synopsis
- Researchers created new 10-deoxoartemisinin derivatives by incorporating heterocyclic rings and hydrophilic groups.
- These new compounds were tested for their effectiveness against malaria.
- Many of the derivatives showed significantly higher potency than artemisinin, with some being 20-25 times more effective against both chloroquine-resistant and sensitive strains of P. falciparum.
Article Abstract
The synthesis of novel 10-deoxoartemisinin derivatives containing heterocyclic rings and hydrophilic groups, and their antimalarial activity assessment are described. Most of the synthesized derivatives are more potent than artemisinin, especially, some of them are 20-25 times more potent than artemisinin to two chloroquine-resistant and sensitive clones of P. falciparum.
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| http://dx.doi.org/10.1016/j.bmcl.2005.03.050 | DOI Listing |
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