AI Article Synopsis
- The study compares the promoter regions of the HSD17B7 genes in humans and mice to understand how these genes are regulated.
- In 1998, HSD17B7 was identified for converting estrone to the more active estradiol, but by 2001, it was suggested to play a role in cholesterol synthesis.
- The research combines bioinformatics and experimental methods to reveal new insights into how HSD17B7 is expressed and its potential link to cholesterol biosynthesis.
Article Abstract
In this study we examined and compared the 5' flanking regions (promoter regions) of human and murine 17beta-hydroxysteroid dehydrogenase type 7 genes (HSD17B7). In 1998, this enzyme was described to convert estrone to biologically more active estradiol. However, in 2001, it was predicted to be involved in cholesterol biosynthesis. To elucidate the mechanism governing HSD17B7 expression and its function, we analyzed the promoter regions by bioinformatic and experimental approaches. Our study provides new insights to the transcriptional regulation of HSD17B7 and further hints to its involvement in cholesterol biosynthesis.
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| http://dx.doi.org/10.1016/j.jsbmb.2005.01.012 | DOI Listing |
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