Secondary metabolism is not only a protective mechanism against biotic and abiotic stresses but also part of the molecular programs that contribute to normal plant growth and development. In this context, secondary metabolism is intimately linked with other aspects of plant differentiation in which transcription factors play a key coordinating role. Recent findings illustrate the complexity of regulatory networks that control flavonoid biosynthesis in Arabidopsis and other species. They also underline the close relationship between secondary metabolism and epidermal and seed differentiation in Arabidopsis, and the central role played by conserved WD40 domain proteins in regulating these processes. This review highlights recent advances in this field and describes how they help our understanding of the molecular regulation of plant secondary metabolism.
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http://dx.doi.org/10.1016/j.pbi.2005.03.006 | DOI Listing |
Biomol NMR Assign
January 2025
Department of Chemistry, Iowa State University, Hach Hall, 2438 Pammel Drive, Ames, IA, 50011, USA.
The Alkbh7 protein, a member of the Alkylation B (AlkB) family of dioxygenases, plays a crucial role in epigenetic regulation of cellular metabolism. This paper focuses on the NMR backbone resonance assignment of Alkbh7, a fundamental step in understanding its three-dimensional structure and dynamic behavior at the atomic level. Herein, we report the backbone H, N, C chemical shift assignment of the full-length human Alkbh7.
View Article and Find Full Text PDFJ Voice
January 2025
Department of Speech, Language, and Hearing Sciences, Auburn University, Auburn, AL.
Purpose: Blood lactate concentration is commonly used to assess metabolic demand and skeletal muscle training response. The objective of the pilot study was to investigate if a change in blood lactate was detectable in an anaerobically designed vocal demand task vocal capacity anaerobic task (VCAT) and determine if the developed vocal demand task may assess the anaerobic capacity of the voice musculature, like anaerobic power tests commonly used in applied exercise science.
Methods: A prospective repeated measures study quantified blood lactate concentration preVCAT and postVCAT in vocally healthy adults.
BMJ Open
January 2025
Documentation and Scientific Information Service, Centro Hospitalar e Universitario de Coimbra EPE, Coimbra, Portugal.
Introduction: This review aims to synthesise research evidence regarding biomarkers in the synovial fluid that may predict the risk of post-traumatic osteoarthritis (PTOA) in young adults. Considering the high prevalence of knee joint injuries, particularly among youth sports athletes, this review will focus on anterior cruciate ligament and/or meniscal ruptures. These injuries are highly associated with PTOA, with studies indicating that even with surgical reconstruction, 50%-80% of affected individuals develop knee PTOA within a 10-year follow-up.
View Article and Find Full Text PDFBMJ Open
January 2025
Public Health School, Jining Medical University, Jining, China
Objectives: To explore whether metabolically healthy overweight (MHOW) and/or metabolically healthy obesity (MHO) increase hyperglycaemia risk in a Chinese population with a broad age range.
Design: Retrospective cohort study.
Setting: Secondary analysis of data from the DATADRYAD database, comprising health check records of participants from 32 regions and 11 cities in China between 2010 and 2016.
J Clin Endocrinol Metab
January 2025
Rijnstate, Dept. of Radiology and Nuclear Medicine, Arnhem, The Netherlands.
Context: Radiofrequency ablation (RFA) is used as treatment for symptomatic thyroid nodules. Factors influencing the volume reduction ratio (VRR) at 12 months are not yet fully understood.
Objective: The primary objective was evaluating the VRR at 12 months after RFA.
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