Background: Aspirin protects from cardiovascular events. However, a number of patients who take this drug suffer events, probably due to aspirin resistance. Our objective was to determine the prevalence of aspirin resistance in patients taking this drug and to test if resistance is related to different variables.
Methods: Platelet function was studied in 113 patients (90 men) aged 63+/-9 (80 with stable ischaemic heart disease) who took aspirin (100 to 300 mg/day). By a platelet function analyzer, called PFA-100, the epinephrine closure time was studied. We also analysed the possible relationship between epinephrine closure time and the following variables: total cholesterol, LDL, HDL cholesterol, total/HDL cholesterol, triglycerides, lipoprotein(a), and C reactive protein. The possible association between aspirin resistance (epinephrine closure time <161 s) and different variables was also analyzed with the SPSS statistical package. Results are expressed in median (interquartile range).
Results: Aspirin resistance was found in 32% of cases. Ischaemic heart disease, smoking habit, and treatment with statins were associated with a significantly greater percent of resistance (p=0.049, 0.009, and 0.043, respectively). Patients with aspirin resistance had higher levels of total/HDL cholesterol: 4.46 (3.76-5.55) vs. 3.97 (3.20-4.75) (p = 0.023); and lipoprotein(a): 57.2 (24.8-85.0) mg/dl vs. 13.1 (3.7-38.0) mg/dl (p = 0.007).
Conclusions: Aspirin resistance is frequent and easily detected by PFA-100. It occurs more frequently in smokers. A mild association is found with ischaemic heart disease, some lipids, and treatment with statins. Our results support the applicability of this method to clinical practice.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.ijcard.2004.03.069 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
PD-L1 positive platelets mediate resistance to immune checkpoint inhibitors in patients with colorectal cancer.
Cell Commun Signal
January 2025
Digestive Disease Center, The First Affiliated Hospital of Jiamusi University, Jiamusi, Heilongjiang Province, 154000, China.
Background: Programmed cell death ligand 1 (PD-L1) expression on immune cells is correlated with the efficacy of immune checkpoint inhibitor (ICI) therapy in various types of cancer. Platelets are important components of the tumour microenvironment (TME) and are widely involved in the development of many types of cancer including colorectal cancer (CRC). However, the role of PD-L1 positive platelets in ICI therapy for CRC remains unknown.
View Article and Find Full Text PDFSelective Serotonin Reuptake Inhibitors and Bleeding Risk in the Geriatric Population.
Innov Clin Neurosci
December 2024
All authors are with Ocean University Medical Center in Brick, New Jersey.
Introduction: The demographics of the United States (US) are evolving as time progresses. The geriatric population is growing, with many elderly people dealing with mental health issues. Major depressive episodes affect 1 to 5 percent of those aged 65 years or older, which emphasizes the importance of addressing mental health concerns in this populace.
View Article and Find Full Text PDFRegulation of macrophage polarization by metformin through inhibition of TLR4/NF-κB pathway to improve pre-eclampsia.
Placenta
January 2025
Department of Obstetrics and Gynecology, Affiliated Xiaoshan Hospital, Hangzhou Normal University, Hangzhou, Zhejiang, 311200, China. Electronic address:
Introduction: Pre-eclampsia (PE) is a pregnancy complication featuring hypertension and proteinuria. Metformin exerts clinically preventive effects on PE with an unspecified mechanism.
Methods: Placental tissues from PE patients and normal pregnant (NP) women were collected.
Complexities, Benefits, Risks, and Clinical Implications of Sodium Bicarbonate Administration in Critically Ill Patients: A State-of-the-Art Review.
J Clin Med
December 2024
Emergency Medicine, Freeman Health System, Joplin, MO 64804, USA.
Sodium bicarbonate has been used in the treatment of different pathologies, such as hyperkalemia, cardiac arrest, tricyclic antidepressant toxicity, aspirin toxicity, acute acidosis, lactic acidosis, diabetic ketoacidosis, rhabdomyolysis, and adrenergic receptors' resistance to catecholamine in patients with shock. An ongoing debate about bicarbonate's efficacy and potential harm has been raised for decades because of the lack of evidence supporting its potential efficacy. Despite the guidelines' restrictions, sodium bicarbonate has been overused in clinical practice.
View Article and Find Full Text PDFProgress Analysis of Personalized Antiplatelet Therapy in Patients with Coronary Heart Disease Undergoing Interventional Therapy.
Rev Cardiovasc Med
December 2024
Department of Emergency, People's Hospital of Dali Bai Autonomous Prefecture, 671000 Dali, Yunnan, China.
Coronary atherosclerosis (or coronary heart disease [CHD]) is a common cardiovascular disease that seriously damages human health. Percutaneous coronary stent implantation represents the primary treatment option for severe CHD in clinical practice; meanwhile, dual antiplatelet therapy (DAPT) is widely used to reduce the risk of postoperative thrombosis. Although the mechanisms of action of the two most commonly used antiplatelet drugs, aspirin and clopidogrel, remain unclear, clinical studies have shown that some patients are susceptible to stent thrombosis-antiplatelet resistance (high on-treatment platelet reactivity [HTPR])-despite using these drugs.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!