AI Article Synopsis
- Dopaminergic addiction in Parkinson's disease can lead to severe behavioral issues like manic psychosis and impulsive behaviors.
- Researchers presented two young patients who experienced disabling motor fluctuations and dyskinesia due to dopamine dysregulation syndrome.
- Deep brain stimulation targeting the subthalamic nucleus not only improved their motor symptoms but also significantly reduced behavioral disorders and eliminated their addiction to dopaminergic treatment.
Article Abstract
In Parkinson's disease, dopamine dysregulation syndrome (DDS) is characterized by severe dopamine addiction and behavioral disorders such as manic psychosis, hypersexuality, pathological gambling, and mood swings. Here, we describe the case of 2 young parkinsonian patients suffering from disabling motor fluctuations and dyskinesia associated with severe DDS. In addition to alleviating the motor disability in both patients, subthalamic nucleus (STN) deep brain stimulation greatly reduced the behavioral disorders as well as completely abolished the addiction to dopaminergic treatment. Dopaminergic addiction in patients with Parkinson's disease, therefore, does not constitute an obstacle to high-frequency STN stimulation, and this treatment may even cure the addiction.
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| http://dx.doi.org/10.1002/mds.20501 | DOI Listing |
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