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Interdisciplinary perspectives on the co-management of metabolic dysfunction-associated steatotic liver disease and coronary artery disease.
Lancet Gastroenterol Hepatol
January 2025
Cardiology Division, NYU Langone Health and NYU School of Medicine, New York, NY, USA. Electronic address:
Metabolic dysfunction-associated steatotic liver disease (MASLD) has emerged as a public health threat as it affects approximately 38% of the adult population worldwide, with its prevalence rising in step with that of obesity and type 2 diabetes. Beyond the implications of MASLD for liver health, it is also associated with cardiovascular and vascular dysfunction. Although the many shared risk factors and common metabolic milieu might indicate that cardiovascular disease and MASLD are discrete outcomes from common systemic pathogeneses, a growing body of evidence has identified a potential causal relationship between MASLD and coronary artery disease, which is the leading cause of morbidity and mortality in people with MASLD and all-cause mortality worldwide.
View Article and Find Full Text PDFEmerging roles of mechanosensitive ion channels in ventilator induced lung injury: a systematic review.
Front Immunol
December 2024
Department of Emergency Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Background: The pathogenetic mechanisms of ventilator-induced lung injury (VILI) still need to be elucidated. The mechanical forces during mechanical ventilation are continually sensed and transmitted by mechanosensitive ion channels (MSICs) in pulmonary endothelial, epithelial, and immune cells. In recent years, MSICs have been shown to be involved in VILI.
View Article and Find Full Text PDFRisk Factors, Treatments, and Outcomes of Adults Aged <55 Years With Acute Ischemic Stroke With Undetermined Versus Determined Pathogenesis: A Nationwide Swiss Cohort Study.
J Am Heart Assoc
December 2024
Department of Neurology University Teaching and Research Hospital St. Gallen St. Gallen Switzerland.
Background: The rising prevalence of acute ischemic stroke (AIS) in young adults, particularly with undetermined pathogenesis, is a growing concern. This study assessed risk factors, treatments, and outcomes between young AIS patients with undetermined and determined pathogeneses.
Methods And Results: This was a retrospective cohort study including AIS patients aged 18 to 55 years in Switzerland, treated between 2014 and 2022.
RNA sequencing analysis reveals distinct gene expression patterns in infrapatellar fat pads of patients with end-stage osteoarthritis or rheumatoid arthritis.
Biochim Biophys Acta Mol Cell Biol Lipids
January 2025
Institute of Biomedicine, School of Medicine, Faculty of Health Sciences, University of Eastern Finland, P.O. Box 1627, FI-70211 Kuopio, Finland. Electronic address:
Article Synopsis
- Osteoarthritis (OA) and rheumatoid arthritis (RA) are both inflammatory joint diseases with overlapping symptoms but distinct causes, potentially linked to adipose tissue like the infrapatellar fat pad (IFP).
- The study aimed to identify key genes and pathways in IFPs of OA and RA patients through RNA sequencing, ultimately looking to enhance diagnostics and develop personalized treatment options.
- Findings revealed significant differences in gene expression between OA and RA, highlighting specific metabolic pathways and suggesting that IFP plays a role in inflammation and cartilage degradation, potentially offering new targets for diagnosis and therapy.
The role of dsRNA A-to-I editing catalyzed by ADAR family enzymes in the pathogeneses.
RNA Biol
January 2024
School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
The process of adenosine deaminase (ADAR)-catalyzed double-stranded RNA (dsRNA) Adenosine-to-Inosine (A-to-I) editing is essential for the correction of pathogenic mutagenesis, as well as the regulation of gene expression and protein function in mammals. The significance of dsRNA A-to-I editing in disease development and occurrence is explored using inferential statistics and cluster analyses to investigate the enzymes involved in dsRNA editing that can catalyze editing sites across multiple biomarkers. This editing process, which occurs in coding or non-coding regions, has the potential to activate abnormal signalling pathways that contributes to disease pathogenesis.
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