Total synthesis of viridiofungin A.

Chem Commun (Camb)

Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8521, Japan.

Published: May 2005

Viridiofungin A, a member of amino alkyl citrate antibiotics from Trichoderma viride, was enantioselectively synthesized in naturally occurring form for the first time, employing regio- and stereoselective opening of the chiral glycidate with vinylmagnesium bromide and alkene cross metathesis of the citric acid core and hexadec-15-en-8-one as key steps.

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http://dx.doi.org/10.1039/b500660kDOI Listing

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