AI Article Synopsis
- Multiple signaling pathways, including Wnt/Frizzled (Fz), are crucial for the development of the vertebrate neural retina.
- Recent research shows that Wnt/Fz components are actively expressed during retinogenesis in species like chick and mouse.
- The review discusses the expression patterns and indicates that Wnt/Fz signaling serves various functions throughout retinal development.
Article Abstract
Multiple signaling pathways are known to be involved in regulating development of the vertebrate neural retina. Recent publications have demonstrated that Wnt/Frizzled (Fz) signaling components are expressed in the developing retina and may play a fundamental role in retinogenesis. In this review, we summarize Wnt/Fz expression patterns in the developing vertebrate retina, mainly from chick and mouse, and compare them with Wnt/beta-catenin reporter activity. Consistent with the dynamic expression patterns of Wnt pathway components, evidence suggests that Wnt/Fz signaling has multiple roles during retinal development.
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| http://dx.doi.org/10.1159/000082277 | DOI Listing |
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