The goal of the study was to investigate biochemical markers of bone metabolism and cortical BMD in young healthy females. 62 young, practically healthy females, 15-35 years of age were involved in this study. Osteoporosis risk factors were assessed by means of the special questionnaire. SOS (speed of sound) was measured in the middle of tibia by ultrasound densitometer Sound Scan Compact (Myriad, Israel). The bone mineral density of 62 young females varied depending on the risk factors such as low body mass, low calcium intake, smoking and unbalanced low calorie diet. Body mass index strongly correlated with the BMD. For effective control and prevention of osteoporosis, it is essential to identify risk-groups among healthy population for follow-up screening and providing adequate measures.
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J Bone Miner Res
January 2025
School of Medical Science, Faculty of Medicine and Health, The University of Sydney, Australia.
Front Immunol
January 2025
Institute for Experimental Immunology and Imaging, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Post-stroke early activation of neutrophils contributes to intensive neuroinflammation and worsens disease outcomes. Other pre-existing patient conditions can modify the extent of their activation during disease, especially hypercholesterolemia. However, whether and how increased circulating cholesterol amounts can change neutrophil activation responses very early after stroke has not been studied.
View Article and Find Full Text PDFFront Med (Lausanne)
January 2025
Department of Spine Surgery, Wuhan Fourth Hospital, Wuhan, China.
Background: Tropical Candida spondylitis is an uncommon cause of lower back pain in patients, especially in non-tropical areas or in patients not at risk of immunocompromise.
Case Presentation: A 65-year-old woman presented with a six-month history of poorly managed low back pain, now accompanied by numbness and pain in both lower extremities. Her medical history was significant for tertiary hypertension.
J Stem Cells Regen Med
October 2024
Mansoura University, Faculty of Science, Zoology department, Mansoura, Dakahlia, Egypt.
In recent years, bone marrow derived mesenchymal stem cells (BM-derived MSCs) have emerged as a powerful cell-based therapy for various diseases, including male infertility. Demonstrating the efficiency of BM-derived MSCs transplantation by different routes of injection to home and repair testis of busulfan-induced azoospermic rats. In the present study, rat BM-derived MSC was isolated and characterized for mesenchymal &hematopoietic markers using flow-cytometry.
View Article and Find Full Text PDFJ Orthop Surg Res
January 2025
Department of Rehabilitation Medicine, Northern Jiangsu People's Hospital, Yangzhou, Jiangsu, 225001, China.
Objective: To explore the mechanism of hyperbaric oxygen therapy in inhibiting subchondral bone angiogenesis and delaying the progression of osteoarthritis through the PHD2/HIF-1α signaling pathway.
Methods: Mice were randomly divided into three groups (control group, osteoarthritis group, and hyperbaric oxygen treatment group). The effect of hyperbaric oxygen therapy on osteoarthritis was evaluated using Micro-CT, Safranin O-Fast Green staining, and detection of osteoarthritis inflammation markers (MMP-13, ADAMTS-5, Col2a1, and Aggrecan).
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