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Analysis of virulence factors in extracellular vesicles secreted by Naegleria fowleri.
Parasitol Res
October 2024
Universidad Nacional Autónoma de México, Grupo CyMA, UIICSE, FES Iztacala, Laboratorio de Microbiología Ambiental, Estado de México, Tlalnepantla de Baz, Mexico.
Article Synopsis
- Naegleria fowleri causes primary amebic meningoencephalitis (PAM), a deadly infection with over 95% mortality, especially in young individuals, and its symptoms resemble other types of meningitis, complicating timely diagnosis.
- Researchers aimed to analyze the virulence factors in extracellular vesicles (EVs) secreted by N. fowleri, employing techniques like SDS-PAGE and RT-PCR for molecular identification.
- The study found that N. fowleri secretes various sized vesicles containing key proteins, including ones recognized by specific antibodies and markers, suggesting these vesicles may play a role in the amoeba’s communication and pathogenicity.
Article Synopsis
- Autoimmune hepatitis (AIH) is uncommon in children but presented uniquely in an 18-year-old female with symptoms like cough, fatigue, and severe anemia.
- Initial tests showed jaundice, low hemoglobin, and other alarming features leading to further investigation, eventually confirming AIH.
- Treatment included intravenous methylprednisolone and maintenance immunosuppression with tacrolimus, emphasizing the need for timely diagnosis and awareness of rare presentations in AIH.
IL-12 drives the differentiation of human T follicular regulatory cells.
Sci Immunol
July 2024
Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
T follicular regulatory (T) cells can counteract the B cell helper activity of T follicular helper (T) cells and hinder the production of antibodies against self-antigens or allergens. A mechanistic understanding of the cytokines initiating the differentiation of human regulatory T (T) cells into T cells is still missing. Herein, we report that low doses of the pro-T cytokine interleukin-12 (IL-12) drive the induction of a T cell program on activated human T cells while also preserving their regulatory function.
View Article and Find Full Text PDFCeliac crisis (CC) is a rare complication of celiac disease (CD), usually observed in younger children with unrecognized CD or poor compliance with a gluten-free diet (GFD). We present a case of celiac crisis in a 3-year-old girl who was recently diagnosed with celiac disease. She was referred to our clinic with anasarca, tetany, and severe malnutrition, with hypokalemia, hypocalcemia, hypomagnesemia, and hypoalbuminemia.
View Article and Find Full Text PDFUnveiling potential adverse events associated with escitalopram oxalate: A real-world analysis based FDA adverse event reporting system database.
J Psychopharmacol
June 2024
Mental Health Center of Jiangnan University, Wuxi Central Rehabilitation Hospital, Jiangsu, China.
Objective: The study aimed to conduct a multidimensional evaluation of potential adverse events (AEs) of escitalopram oxalate based on the FDA adverse event reporting system (FAERS) database.
Methods: This study utilized the reporting odds ratio (ROR), proportional reporting ratio (PRR), Bayesian confidence propagation neural network (BCPNN), and multi-item gamma-poisson shrinker (MGPS) to mine and analyze data from the FAERS database from the first quarter of 2004 to the second quarter of 2023.
Results: There was a total of 19,854 AE reports related to escitalopram oxalate, extracting 625 preferred terms (PTs), and covering 27 system organ classes (SOCs).
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