Objective: To evaluate the perioperative management and safety of pulmonary thromboendarterectomy for chronic pulmonary thromboembolism.
Methods: From March 1999 to March 2004, 12 patients with chronic pulmonary thromboembolism received thromboendarterectomy. The operation was performed under cardio-pulmonary bypass with low flow or circulative arrest and deep hypothermia. The clinical data of the 12 cases were reviewed retrospectively.
Results: Pulmonary pressure immediately decreased 20 to 40 mm Hg (1 mm Hg = 0.133 kPa) after operation in 6 cases. Various degrees of postoperative pulmonary edema happened in 8 cases. One patient died at the 19th day after operation due to severe lung infection and pulmonary re-embolism. Eleven patients were followed-up for 2 months to 5 years, the clinical symptom and routine daily activity were improved after surgery.
Conclusion: Pulmonary thromboendarterectomy is an effective treatment for chronic pulmonary thromboembolism. It is very important to management of postoperative reperfusion injury and pulmonary edema. A key point to enhance the safety of surgical treatment for chronic pulmonary thromboembolism is preoperative correct evaluation and indication selection.
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Am J Respir Cell Mol Biol
January 2025
National Heart & Lung Institute, Imperial College London, Airway Disease Section, London, United Kingdom of Great Britain and Northern Ireland.
Chronic obstructive pulmonary disease (COPD) is associated with the acceleration of lung aging, and the accumulation of senescent cells in lung tissue. MicroRNA (miR)-34a induces senescence by suppressing the anti-aging molecule, sirtuin-1 (SIRT1). Senescent cells spread senescence to neighbouring and distant cells, favouring COPD progression and its comorbidities.
View Article and Find Full Text PDFRadiol Cardiothorac Imaging
February 2025
From the Department of Biomedical Engineering (X.Z.) and Columbia Magnetic Resonance Research Center (CMRRC) (W.S.), Columbia University, New York, NY; Departments of Medicine (C.B.C., J.P.F.) and Radiology (J.P.F.), University of California at Los Angeles, Los Angeles, Calif; Department of Radiology, Weill Cornell Medicine, New York, NY (M.R.P.); Department of Radiology (M.R.P., S.M.D., S.J.), Department of Medicine (M.C.B., R.G.B.), Department of Epidemiology (R.G.B.), Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics (W.S.), and Institute of Human Nutrition (W.S.), Columbia University Irving Medical Center, 632 W 168th St, PH-17, New York, NY 10032; Department of Radiology (B.A.V., J.A.C.L.) and Division of Pulmonary and Critical Care Medicine, Department of Medicine, School of Medicine (N.N.H.), Johns Hopkins University, Baltimore, Md; Department of Radiology, University of Michigan, Ann Arbor, Mich (P.P.A.); Department of Radiology, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wis (D.A.B.); Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC (D.C.); Departments of Radiology, Medicine, and the Roy J. Carver Department of Biomedical Engineering, University of Iowa, Iowa City, Iowa (E.A.H.); Sections on Cardiology and Geriatrics, Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC (D.W.K.); Division of Pulmonary, Critical Care, Sleep, and Allergy (J.A.K.) and Department of Radiology, College of Medicine (M.G.M.), University of Illinois at Chicago, Chicago, Ill; Department of Radiology and Biomedical Imaging (Y.J.L., J.L.), Division of Pulmonary, Critical Care, Sleep, and Allergy, Department of Medicine, School of Medicine (P.G.W.), and Cardiovascular Research Institute (P.G.W.), University of California at San Francisco, San Francisco, Calif; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Wake Forest University, Winston-Salem, NC (J.O., S.P.P.); Division of Pulmonary Medicine, Department of Medicine, Mayo Clinic, Phoenix, Ariz (V.E.O.); Department of Medicine, University of Utah, Salt Lake City, Utah (R.P.); Department of Radiology, Mayo Clinic, Rochester, Minn (J.D.S.); Department of Radiology, Hannover Medical School, Hannover, Germany (J.V.C.); and BREATH, Member of the German Center for Lung Research (DZL), Hannover, Germany (J.V.C.).
Purpose To assess the repeatability of real-time cine pulmonary MRI measures of metronome-paced tachypnea (MPT)-induced dynamic hyperinflation and its relationship with chronic obstructive pulmonary disease (COPD) severity. Materials and Methods SubPopulations and InteRmediate Outcome Measures In COPD Study (SPIROMICS) (ClinicalTrials.gov identifier no.
View Article and Find Full Text PDFAm J Respir Cell Mol Biol
January 2025
Wayne State University, Division of Pulmonary, Critical Care and Sleep Medicine, Detroit, Michigan, United States;
Numerous chronic human disorders are associated with immune activation by obscure antigen(s). We identified a novel sarcoidosis-epitope (ChainA) by immunoscreening of a novel T7 phage library and confirmed an abundance of ChainA IgG-antibody in sarcoidosis. We tested whether ChainA epitope elicits immune responses through B-cell activation, plasma cell differentiation and antibody production.
View Article and Find Full Text PDFAnn Am Thorac Soc
January 2025
University of Pittsburgh, Pulmonary, Allergy and Critical Care Medicine, Pittsburgh, Pennsylvania, United States.
Front Med (Lausanne)
January 2025
Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Background: Idiopathic pulmonary fibrosis (IPF) is an interstitial lung disease characterized by chronic inflammation and progressive fibrosis. The blood urea nitrogen-to-albumin ratio (BAR) is a comprehensive parameter associated with inflammation status; however, it is unknown whether the BAR can predict the prognosis of IPF.
Methods: This retrospective study included 176 patients with IPF, and 1-year all-cause mortality of these patients was recorded.
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