Cancer-related fatigue is one of the most common and disabling conditions referred by patients with neoplastic diseases. However, it is one of the symptoms related to cancer and its treatment, oncologists largely underestimate. The guidelines of the National Comprehensive Cancer Network on the diagnosis and treatment of this multifactorial pathology are illustrated. Attention is focused on the most recent evidences present in the literature about the therapeutic benefit of physical exercise and its effects on muscular function, cardiorespiratory performance and life quality of oncologic patients.
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