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Very High-Energy Electron Therapy Toward Clinical Implementation.
Cancers (Basel)
January 2025
Intense Laser Irradiation Laboratory, National Institute of Optics, National Research Council of Italy, 56124 Pisa, Italy.
The use of very high energy electron (VHEE) beams, with energies between 50 and 400 MeV, has drawn considerable interest in radiotherapy due to their deep tissue penetration, sharp beam edges, and low sensitivity to tissue density. VHEE beams can be precisely steered with magnetic components, positioning VHEE therapy as a cost-effective option between photon and proton therapies. However, the clinical implementation of VHEE therapy (VHEET) requires advances in several areas: developing compact, stable, and efficient accelerators; creating sophisticated treatment planning software; and establishing clinically validated protocols.
View Article and Find Full Text PDFExamination of immunohistochemical of the effects of flattened and unflattened radiotherapy beams in nude mice breast cancer xenografts.
Int J Radiat Biol
January 2025
Department of Neurosurgery, Haydarpasa Numune Training and Research Hospital, Istanbul, Turkey.
Purpose: The aim of this study was to investigate the radiobiological effects underlying the inhibition of breast cancer (BCa) following radiotherapy in nude mice models, and to evaluate the impact of changes in immunohistochemical parameters induced by FF and FFF beams.
Materials And Methods: The study included thirty-six adult nude mouse models, which were randomly assigned to five groups: control (G1), breast cancer (BCa) (G2), FF-400 MU/min (G3), FFF-1100 MU/min (G4), and FFF-1800 MU/min (G5). The control group received neither radiation nor treatment, while the BCa group had a cancer model without radiation.
Design and construction of gradient coils for an MRI-guided small animal radiation platform.
Heliyon
February 2024
Innovative Technology Of Radiotherapy Computations and Hardware (iTORCH) Laboratory, Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, 75390, TX, USA.
Small animal radiation experiments use a dedicated hardware platform to deliver radiation to small animals to support pre-clinical radiobiological studies. Image guidance is critical to achieve experiment accuracy. MR-based image guidance became recently available in human radiation therapy by integrating an MR scanner with a medical linear accelerator.
View Article and Find Full Text PDFRadiobiology and modelling in Brachytherapy: A review inspired by the ESTRO Brachytherapy pre-meeting course.
Clin Transl Radiat Oncol
January 2025
Antoine Lacassagne Cancer Center - University Côte d'Azur, Nice, France.
Brachytherapy (BT) plays a key role in cancer treatment by delivering a high dose to a small volume over a short time. The use of BT is currently validated in a wide range of cancers such as cervical, prostate and breast cancers while being a favourable choice for organ preservation, such as in penile or rectal cancer, or in the setting of reirradiation. Consideration of the radiobiology of BT is integral to the choices made around dose and fractionation and combination with other techniques such as external beam radiotherapy (EBRT).
View Article and Find Full Text PDFUnderstanding Permeability Changes in Vestibular Schwannomas as Part of the Dynamic Response to Radiosurgery Using Golden-Angle Radial Sparse Parallel Imaging: A Retrospective Study.
Neurosurgery
December 2024
Department of Neurosurgery, NYU Grossman School of Medicine, New York , New York , USA.
Background And Objectives: Vestibular schwannomas demonstrate different responses after stereotactic radiosurgery (SRS), commonly including a transient loss of internal enhancement on postcontrast T1-weighted MRI thought to be due to an early reduction in tumor vascularity. We used dynamic contrast-enhanced based golden-angle radial sparse parallel (GRASP) MRI to characterize the vascular permeability changes underlying this phenomenon, with correlations to long-term tumor regression.
Methods: Consecutive patients with vestibular schwannoma who underwent SRS between 2017 and 2019, had a transient loss of enhancement after SRS, and had long-term longitudinal GRASP studies (6, 18, and 30 months) were included in this retrospective cohort analysis (n = 19).
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