AI Article Synopsis
- The aqueous extract of Phyllanthus orbicularis shows antiviral activity against herpes simplex virus type 1 and HIV-1 in cell cultures and in Balb-c mice.
- The extract demonstrated a selective index of 44, indicating a potential virucidal effect on the virus particles.
- In vivo trials revealed that topical application significantly reduced lesion development in mice infected with HIV-1.
Article Abstract
The antiviral activity of the aqueous extract of Phyllanthus orbicularis, a member of the Euohorbiacea family, against the simple herpes virus typel was evaluated in cellular culture, specifically in fibroblasts of human prepucium, and in an animal model, Balb-c mice. The extracelullar effect of the extract on HIV-1 proved to be effective. A selective index of 44 was obtained, which shows a possible virucidal action on the particle. In the trial in vivo, the topical administration of the aqueous extract (12 mg/kg) reduced significantly the development of lesions in mice subcutaneously infected with HIV-1 (1 x 106 UFP). These results suggest the consideration of Phyllanthus orbicularis as a possible anti-HIV-1 candidate
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