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Accounting for Twins and Other Multiple Births in Perinatal Studies of Live Births Conducted Using Healthcare Administration Data.
Epidemiology
March 2025
From the Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA.
The analysis of perinatal studies is complicated by twins and other multiple births even when multiples are not the exposure, outcome, or a confounder of interest. In analyses of infant outcomes restricted to live births, common approaches to handling multiples include restriction to singletons, counting outcomes at the pregnancy level (i.e.
View Article and Find Full Text PDFPer- and Polyfluoroalkyl Substances and Twin Growth Discordance: New Insights from a Twin Birth Cohort Study.
Environ Sci Technol
January 2025
Guangdong Key Laboratory of Environmental Pollution and Health, College of Environment and Climate, Jinan University, Guangzhou 510632, China.
Prenatal exposure to per- and polyfluoroalkyl substances (PFASs) has been linked to adverse fetal growth and development. However, most evidence was generated based on the singleton pregnancy studies, whereas potential impact on twin fetuses remains largely unknown. This study aimed to explore the associations of prenatal PFAS exposure with the growth and developmental differences within twin pairs by investigating 162 twin newborns and their mothers and determining 19 PFASs in maternal serum during the first, second, and third trimesters and cord serum of twins.
View Article and Find Full Text PDFReport of the 19th International Congress on Twin Studies, 26-28 September 2024, Assisi, Italy.
Twin Res Hum Genet
January 2025
Medical Imaging Centre, Semmelweis University, Budapest, Hungary.
The International Society for Twin Studies (ISTS) held its 19th scientific congress in Assisi, Italy, from September 26 to 28, 2024. This prestigious event, which was the seventh joint meeting with the World Congress on Twin Pregnancy, brought together researchers from various fields, including psychology, biology and medicine. Representatives from ICOMBO (the International Consortium of Multiple Birth Organisations), which supports multiple-birth families worldwide, were also in attendance.
View Article and Find Full Text PDFFrozen versus fresh embryo transfer in women with low prognosis for in vitro fertilisation treatment: pragmatic, multicentre, randomised controlled trial.
BMJ
January 2025
State Key Laboratory of Reproductive Medicine and Offspring Health, Centre for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University, Jinan, China
Objective: To test the hypothesis that a freeze-all strategy would increase the chance of live birth compared with fresh embryo transfer in women with low prognosis for in vitro fertilisation (IVF) treatment.
Design: Pragmatic, multicentre, randomised controlled trial.
Setting: Nine academic fertility centres in China.
Independent risk factors for twin pregnancy adverse fetal outcomes before 28 gestational week by first trimester ultrasound screening.
World J Radiol
January 2025
Department of Ultrasound, Shanghai Changning Maternity and Infant Health Hospital, East China Normal University, Shanghai 200050, China.
Background: The incidence of multiple pregnancies has increased worldwide recently and women with a twin pregnancy are at higher risk of adverse outcomes compared with women with a singleton pregnancy. It is important to understand the risk factors for adverse fetal outcomes in twin pregnancy in order to guide clinical management.
Aim: To identify the independent risk factors, including maternal personal and family medical histories and first trimester ultrasound screening findings, for adverse fetal outcomes of twin pregnancy before 28 weeks of gestation.
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