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The association between knockdown resistance and treatment outcome of 1% permethrin lotion in head lice infestations in Nonthaburi province, Thailand.
Arch Dermatol Res
October 2024
Department of Parasitology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Head lice infestations significantly impact schoolchildren, with permethrin being the primary treatment. The escalation in the prevalence of the knockdown resistance (kdr) mutation, potentially affecting treatment efficacy, is highly concerning. This study examined head lice infestation prevalence, the efficacy of 1% permethrin lotion, kdr mutation frequency, and the association between kdr genotype and permethrin treatment outcomes in schoolchildren in Nonthaburi province, Thailand.
View Article and Find Full Text PDFEffectiveness and chemical insights: Exploring interactions between nanomicelles and monoterpenoids for head lice treatment.
Pestic Biochem Physiol
May 2024
Instituto de Ecología y Desarrollo Sustentable (INEDES, CONICET-UNLu), Ruta 5 y Avenida Constitución 6700, Luján, Buenos Aires, Argentina.
This study evaluates the pediculicidal activity of nanoformulations containing different binary essential oil component mixtures (eugenol:linalool, 1,8 -cineole:linalool, and eugenol:thymol) using immersion bioassays. These have allowed us to evaluate the knockdown time affecting 50% of the individuals (KT). In addition, the type of interaction between the components in each mixture was established in terms of the combination index (IC).
View Article and Find Full Text PDFThe effect of educational intervention on efficacy of 1% permethrin shampoo and 4% dimeticone lotion to treat head lice infestation using propensity score matching (PSM).
BMC Infect Dis
January 2024
Department of Medical Entomology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Article Synopsis
- Head lice are a significant public health issue, and improper application of pediculicides is a common reason for treatment failure; this study aimed to evaluate how education affects the effectiveness of treatments using 1% permethrin or 4% dimeticone lotion.
- Conducted with 100 individuals receiving educational interventions and 400 controls, the study used propensity score matching to account for various factors affecting treatment outcomes from April to March 2019.
- The findings revealed that those who received educational training were about three times more likely to successfully eliminate head lice compared to the control group, highlighting the importance of proper education in treatment effectiveness.
Comparative efficacy of chemical and botanical pediculicides in Thailand and 4% dimeticone against head louse, Pediculus humanus capitis.
PLoS One
June 2023
Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Head louse infestations remain a global public-health concern due to increased resistance of lice to artificial pediculicides. In Thailand, there is a lack of comparative data on the current efficacy of pediculicides for treating head lice. In this study, we explored the status of botanical and toxic synthetic pediculicides with that of 4% dimeticone liquid gel for treating head lice in Thailand.
View Article and Find Full Text PDFPhysically Acting Treatments for Head Lice-Can We Still Claim They Are 'Resistance Proof'?
Pharmaceutics
November 2022
Medical Entomology Centre, Insect Research & Development Limited, 6 Quy Court, Colliers Lane, Stow-cum-Quy, Cambridge CB25 9AU, UK.
Head lice worldwide have developed resistance to insecticides, prompting the introduction of a range of alternative treatments including plant extracts and natural and synthetic oils. Clinical studies of physically acting treatments showed them to be highly effective when first introduced, and a widely held, but unsubstantiated, belief is that lice are unlikely to develop resistance to them. However, this ignores possibilities for natural selection of traits enabling lice to survive exposure.
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