Current criteria regarding hypertension in pregnancy consider two distinct types: gestational hypertension (pure type) and preeclampsia-eclampsia syndrome, the latter with albuminuria as a mandatory clinical fact. However, reports of lasts years show that a 15 to 46% of cases classified as pure type gestational hypertension evolve to a preeclamptic state, underlying the possibility that both clinical conditions represent diferent stages of the same disease. On the other hand, albuminuria may not be present in severe cases of pregnancy-related hypertensive disorders such as HELLP syndrome or eclampsia. It follows that if albuminuria is not necessary to establish the most severe forms of the disease, must the non-albuminuric hypertensive-type still be considered as a diferent diagnosis? This report reviews the medical literature on the subject, stressing similarities and diferences of both conditions in order to reflect about the need to change the classification concepts pregnancy-related hypertensive entities.
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PLoS One
January 2025
Department of Radiology, The First People's Hospital of Xiaoshan District, Xiaoshan Affiliated Hospital of Wenzhou Medical University, Hangzhou, Zhejiang, China.
Background: Previous studies have shown that higher uterine artery pulsatility index (UtA-PI) values in early pregnancy have predictive value for the risk of preeclampsia (PE). However, the sensitivity and specificity of this marker remain controversial. This study aims to explore further the association between UtA-PI in early pregnancy and the incidence of preeclampsia.
View Article and Find Full Text PDFPediatr Surg Int
January 2025
Division of Neonatology, The Hospital for Sick Children, Toronto, ON, Canada.
Introduction: Congenital diaphragmatic hernia (CDH) in the preterm population is increasingly common in the current era of fetal endoluminal tracheal occlusion (FETO) therapy. There remains a lack of clinical guidance for clinicians and surgeons regarding optimal management strategies for such infants. We aimed to describe our experience in managing preterm CDH in a single quaternary neonatal intensive care unit (NICU).
View Article and Find Full Text PDFBMC Pregnancy Childbirth
January 2025
Department of Clinical Laboratory, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, China.
Background: The connection between fibroblast growth factor 21 (FGF21) and the likelihood of gestational diabetes mellitus (GDM) or preeclampsia (PE) has received more attention recently. Based on published articles, meta-analysis were conducted to explore the differences in FGF21 levels in GDM or PE compared to control groups.
Methods: Articles published before April 5, 2024 were searched across four databases: PubMed, Web of Science, Embase, and Cochrane Library, and studies exploring the association of FGF21 levels and GDM or PE were collected.
Circ Res
January 2025
Department of Medicine, Division of Clinical Pharmacology; and Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN (M.R.A.).
Adv Clin Chem
January 2025
Department of Obstetrics and Gynecology, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. Electronic address:
Preeclampsia (PE), a pregnancy-related syndrome, has motivated extensive research to understand its pathophysiology and develop early diagnostic methods. 'Omic' technologies, focusing on genes, mRNA, proteins, and metabolites, have revolutionized biological system studies. Urine emerges as an ideal non-invasive specimen for omics analysis, offering accessibility, easy collection, and stability, making it valuable for identifying biomarkers.
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