Objectives: Past and present formaldehyde measurements made in facilities manufacturing reconstituted wood panels in Quebec have been collected in order to assess formaldehyde exposure and its determinants in this industry.
Methods: All 12 plants manufacturing Oriented-strand board (OSB), Medium density fibreboard (MDF) and Particle board (PB) in Quebec were visited by a research team which took area and personal measurements. Past measurements taken by governmental occupational health teams in these plants were also collected. Log-transformed formaldehyde concentrations were analysed with extended linear mixed-effects models.
Results: During 2001-2002, 275 measurements were taken by the research team, while 590 measurements dating back to 1984 were collected from governmental files. The area measurements had a global geometric mean (GM) of 0.28 p.p.m. [geometric standard deviation (GSD): 3.1]. The GM of the personal measurements was 0.17 p.p.m. (GSD: 2.3). The fixed-effects of the models for personal and area measurements explained 61 and 57% of the variance, respectively. Job (working area for area concentrations), process (PB, MDF, OSB), season of sampling, origin of the data (research, governmental) and year of sampling were significant determinants of exposure. Proximity to the press, winter conditions, PB and MDF processes and governmental data resulted in the highest exposures. Significant within-sampling campaign correlation was found for both personal and area models. The final models include different residual variances by process for personal measurements and by working area for area measurements.
Conclusions: Several determinants of exposure to formaldehyde in the reconstituted wood panel industry were successfully identified. Higher levels found in governmental data as compared to research data may be explained by a 'worst-case' strategy bias. The observed intra-sampling campaign correlation supports existing results suggesting that measurements taken in a small time frame tend to be correlated. Exposures in this sector are low compared to most 8 h-TWA occupational exposure limits (e.g. 1 p.p.m.) but close to the most demanding ones (e.g. 0.3 p.p.m.).
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http://dx.doi.org/10.1093/annhyg/mei014 | DOI Listing |
Sci Prog
November 2024
Chemical Analysis & Physical Testing Institute, Shenzhen Center for Disease Control and Prevention, Shenzhen, China.
Objectives: The objective of this study was to develop and validate an automated solid-phase extraction (SPE) coupled with ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method for the detection of sodium pentachlorophenolate (PCP-Na) residues on cutting boards. Given the potential hazards and environmental persistence of PCP-Na, a sensitive and reliable method is crucial for monitoring its residues in food contact materials to ensure consumer safety.
Methods: Wood shavings from cutting boards were extracted using 10% methanol in water, followed by purification using an automated SPE system.
Cell Rep
September 2024
Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA; Departments of Cell Biology and Neurobiology, Duke University Medical Center, Durham, NC 27710, USA; Duke Institute for Brain Sciences and Duke Regeneration Center, Duke University Medical Center, Durham, NC 27710, USA. Electronic address:
The exon junction complex (EJC), nucleated by EIF4A3, is indispensable for mRNA fate and function throughout eukaryotes. We discover that EIF4A3 directly controls microtubules, independent of RNA, which is critical for neural wiring. While neuronal survival in the developing mouse cerebral cortex depends upon an intact EJC, axonal tract development requires only Eif4a3.
View Article and Find Full Text PDFJ Biol Chem
July 2024
Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Center, Houston, Texas, USA. Electronic address:
Theta-mediated end joining (TMEJ) is critical for survival of cancer cells when other DNA double-stranded break repair pathways are impaired. Human DNA polymerase theta (Pol θ) can extend ssDNA oligonucleotides, but little is known about preferred substrates and mechanism. We show that Pol θ can extend both ssDNA and RNA substrates by unimolecular stem-loop synthesis initiated by only two 3' terminal base pairs.
View Article and Find Full Text PDFInt J Biol Macromol
May 2024
Institute of Biomaterials for Bamboo and Rattan Resources, International Centre for Bamboo and Rattan, Beijing 100102, China. Electronic address:
The development of modern construction and transportation industries demands increasingly high requirements for thin, lightweight, high-strength, and highly tough composite materials, such as metal carbides and concrete. Bamboo is a green, low-carbon, fast-growing, renewable, and biodegradable material with high strength and toughness. However, the density of its inner layer is low due to the functional gradient (the volume fraction of vascular bundles decreases from the outer layer to the inner layer), resulting in low performance, high compressibility, and significant amounts of bamboo waste.
View Article and Find Full Text PDFAnn Pharmacother
December 2024
Department of Pharmacy Practice and Administration, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ, USA.
Objective: This review evaluates the efficacy and safety of novel respiratory syncytial virus (RSV) vaccines approved for adults aged 60 years and older.
Data Sources: A literature search through February 27, 2024 was conducted using search terms, such as RSV, viral respiratory illness, vaccine, RSVpreF, RSVpreF3, Prefusion F, Abrysvo, and Arexvy.
Study Selection And Data Extraction: Data from primary literature and vaccine prescribing information were reviewed, encompassing evaluations of clinical pharmacology, efficacy, safety, adverse events, warnings, and precautions.
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