The role of tumor necrosis factor alpha (TNF-alpha) in Chlamydia pneumoniae atherogenesis was evaluated in TNF-alpha p55 receptor-deficient C57BL/6J mice fed a high-fat/high-cholesterol diet. No acceleration of atherosclerotic lesion development was observed in infected mice compared to uninfected mice, indicating that TNF-alpha plays a role in the acceleration of atherosclerosis by C. pneumoniae.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1087380 | PMC |
http://dx.doi.org/10.1128/IAI.73.5.3164-3165.2005 | DOI Listing |
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