A mixture of DNA plasmids expressing five Plasmodium falciparum pre-erythrocyte-stage antigens was administered with or without a DNA plasmid encoding human granulocyte-macrophage colony-stimulating factor (hGM-CSF) as an immune enhancer. After DNA immunization, antigen-specific gamma interferon (IFN-gamma) responses were detected by ELISPOT in 15/31 volunteers to multiple class I- and/or class II-restricted T-cell epitopes derived from all five antigens. Responses to multiple epitopes (
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1087336 | PMC |
| http://dx.doi.org/10.1128/IAI.73.5.2863-2872.2005 | DOI Listing |
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