[reaction: see text] The synthesis of 6,11-dihydro-5H-indeno[1,2-c]isoquinolin-5-ones from the base-promoted condensation reaction of homophthalic anhydride and 2-(bromomethyl)-benzonitrile and a convenient method for the synthesis of indolo[3,2-c]isoquinolinones are described.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/ol050331m | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Enhanced room temperature ammonia gas sensing based on a multichannel PSS-functionalized graphene/PANI network.
Analyst
January 2025
Guangdong Provincial Key Laboratory of Electronic Functional Materials and Devices, Huizhou University, Huizhou, 516007, China.
Disordered polymerization of polymers widens the polymerization degree distribution, which leads to uncontrollable thickness and significantly weakens their sensing performance. Herein, poly(sodium -styrenesulfonate)-functionalized reduced graphene oxide (PSS-rGO) with multichannel chain structures coated with thin polyaniline layer (PSS-rGO/PANI) nanocomposites was synthesized a facile interfacial polymerization route. The morphology and microstructure of the PSS-rGO/PANI nanocomposites were characterized using Fourier transform infrared (FTIR) spectroscopy, Raman spectroscopy, X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), and scanning electron microscopy (SEM).
View Article and Find Full Text PDFMultipurpose triadic MXene/garlic/gellan gum-based architecture in the horizon of bone tissue regeneration.
Nanoscale
January 2025
Department of Orthopedic Surgery, The Second Hospital of Dalian Medical University, No. 467, Zhongshan Road, Shahekou District, Dalian City, Liaoning 116021, China.
The use of bioresorbable compositions has been considered a promising therapeutic approach for treating compromised bone tissues. Gellan gum (GG) is a predominant polysaccharide recognized for its exceptional biocompatibility and biodegradability, facile bio-fabrication, and customizable mechanical attributes, rendering it well-suited for developing versatile bone scaffolds. On the other hand, MXene nanosheets have been declared a representational filler to augment the osteogenic effect and amend the mechanical properties of the polymeric biomaterials.
View Article and Find Full Text PDFTumor-Associated Macrophages Nano-Reprogrammers Induce "Gear Effect" to Empower Glioblastoma Immunotherapy.
Small
January 2025
Cancer Hospital of Dalian University of Technology, Dalian University of Technology, Shenyang, 110042, China.
Glioblastoma (GBM), the most malignant brain tumor with high prevalence, remains highly resistant to the existing immunotherapies due to the significant immunosuppression within tumor microenvironment (TME), predominantly manipulated by M2-phenotypic tumor-associated macrophages (M2-TAMs). Here in this work, an M2-TAMs targeted nano-reprogrammers, MG5-S-IMDQ, is established by decorating the mannose molecule as the targeting moiety as well as the toll-like receptor (TLR) 7/8 agonist, imidazoquinoline (IMDQ) on the dendrimeric nanoscaffold. MG5-S-IMDQ demonstrated an excellent capacity of penetrating the blood-brain barrier (BBB) as well as selectively targeting M2-TAMs in the GBM microenvironment, leading to a phenotype transformation and function restoration of TAMs shown as heightened phagocytic activity toward tumor cells, enhanced cytotoxic effects, and improved tumor antigen cross-presentation capability.
View Article and Find Full Text PDFRapid on-site colorimetric detection of arsenic(V) by NH-MIL-88(Fe) nanozymes-based ultraviolet-visible spectroscopic and smartphone-assisted sensing platforms.
Anal Chim Acta
January 2025
College of Resources and Environment, Southwest University, Chongqing, 400716, China; Key Laboratory of Biomedical Analytics (Southwest University), Chongqing Science and Technology Bureau, College of Pharmaceutical Sciences, Southwest University, Chongqing, 400715, China. Electronic address:
Background: Because arsenate (As(V)) is a highly toxic pollutant, timely on-site monitoring of its concentration is crucial for mitigating potential environmental and health hazards. Traditional on-site detection methods for As(V) often face limitations of long response time and low sensitivity. Nanozymes are nanomaterials that exhibit enzyme-like catalytic activity.
View Article and Find Full Text PDFDevelopment of a Coumarin-Based Schiff Base Fluorescent Probe and its Application in Detection of Cu²⁺.
J Fluoresc
January 2025
College of Chemistry and Chemical Engineering, Henan University of Technology, Zhengzhou, 450001, China.
A highly practical Schiff base fluorescent probe, (E)-3-amino-N'-((7-(diethylamino)-2-oxo-2 H-chromen-3-yl)methylene)thiophene-2-carbohydrazide (M), with a facile synthetic route has been successfully developed. M has been utilized for the specific detection of Cu in THF/HO Tris buffer solution (v/v = 9:1, 0.01 M, pH = 7.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!