Objective: To explore the quantitative evaluation of upper airway by CT scan with Muller maneuver, and study the difference of the pharynx wall resilience between OSAHS patients and normal adults.
Method: Twenty-five patients with OSAHS and 20 normal adults were included in the study. CT evaluated the upper airway from roof of nasopharynx to glottis with the use of a Phlips Tomoscan AV Expander E1 spiral scanner. The cross section area and the dimension of palate, uvula, lingua and epiglottis region upper airway were studied. Then repeated the same scan process when testee play-ed Muller maneuver, and calculated the total pharynx wall resilience (TPWR), lateral pharynx wall resilience (LPWR) and anterior post-pharynx wall resilience (APPWR) of different levels of upper airway.
Result: Between OSAHS patients and normal adults, there are obviously difference in the TPWR and LPWR of palate, uvula, lingua region upper airway, and no difference in epiglottis region upper airway. There are obviously difference in the APPWR of palate and uvula region upper airway, and no difference in lingua and epiglottis region upper airways. The LPWR is much more than APPWR in all four level of upper airway in both OSAHS patients and normal adults.
Conclusion: The study suggest that we can get quantitative data of upper airways by CT scan. And there are obviously TPWR, LPWR and APPWR difference at different levels of upper airway between OSAHS patients and normal adult, the increasing of TPWR, LPWR and APPWR is one etiology of OSAHS.
Download full-text PDF |
Source |
---|
Sci Rep
January 2025
Hubrecht Institute-KNAW and University Medical Center Utrecht, Utrecht, The Netherlands.
Pseudomonas aeruginosa is a Gram-negative bacterium that is notorious for airway infections in cystic fibrosis (CF) subjects. Bacterial quorum sensing (QS) coordinates virulence factor expression and biofilm formation at population level. Better understanding of QS in the bacterium-host interaction is required.
View Article and Find Full Text PDFSleep
January 2025
Department of Otorhinolaryngology Head and Neck Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 600 Yishan Road, Shanghai, China.
Study Objectives: Multilevel upper airway surgery is effective for some patients with obstructive sleep apnea (OSA), but prediction the response to surgery remains a challenge. The underlying endotypes of OSA include upper airway collapsibility, muscle compensation, loop gain, and the arousal threshold. This study aimed to explore the effect of surgery on polysomnography (PSG)-derived OSA endotypes and establish a surgical response prediction model.
View Article and Find Full Text PDFOral Radiol
January 2025
Oral and Dental Disease Research Center, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
Objectives: The current study was conducted to assess the volume of the tongue, oral cavity, and tongue/oral cavity and their correlation with the volume of the upper airway in cleft subjects compared with the control group.
Methods: The study population included 60 CBCT images from dental school. The sample comprised 30 unilateral cleft patients and 30 sex and age-matched healthy subjects.
PLoS One
January 2025
Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, United States of America.
Current understanding of viral dynamics of SARS-CoV-2 and host responses driving the pathogenic mechanisms in COVID-19 is rapidly evolving. Here, we conducted a longitudinal study to investigate gene expression patterns during acute SARS-CoV-2 illness. Cases included SARS-CoV-2 infected individuals with extremely high viral loads early in their illness, individuals having low SARS-CoV-2 viral loads early in their infection, and individuals testing negative for SARS-CoV-2.
View Article and Find Full Text PDFCrit Care
January 2025
Keenan Centre for Biomedical Research, Li Ka Shing Knowledge Institute, Unity Health Toronto, Toronto, ON, Canada.
Background: In patients with acute hypoxemic respiratory failure (AHRF) under mechanical ventilation, the change in pressure slope during a low-flow insufflation indicates a global airway opening pressure (AOP) needed to reopen closed airways and may be used for titration of positive end-expiratory pressure.
Objectives: To understand 1) if airways open homogeneously inside the lungs or significant regional AOP variations exist; 2) whether the pattern of the pressure slope change during low-flow insufflation can indicate the presence of regional AOP variations.
Methods: Using electrical impedance tomography, we recorded low-flow insufflation maneuvers (< 10 L/min) starting from end-expiratory positive pressure 0-5 cmHO.
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!