[The expression of p73 and c-fos protein in hemangioma and its significance].

Objective: To investigate the expression of p73 and c-fos protein and its significance in the development of children hemangioma.

Methods: The quantitative expressions of p73 and c-fos protein in hemangioma and normal skin were detected by immunohistochemistry.

Results: The expressions of p73 and c-fos protein were strong in proliferative hemangioma while they were very weak in involutional hemangioma and normal skin. There were significant differences between the proliferative and involutional hemangioma or the normal skin in the expressions of p73 and c-fos (P < 0.01). No statistical significances of p73 or c-fos P73 expressions were observed between involutional hemangioma and normal skin (P > 0.05).

Conclusions: P73 and c-fos may play an important role in the development and involution of skin hemangioma.