We obtained a neurotoxic fraction (AcTx) from star fruit (Averrhoa carambola) and studied its effects on GABAergic and glutamatergic transmission systems. AcTx had no effect on GABA/glutamate uptake or release, or on glutamate binding. However, it specifically inhibited GABA binding in a concentration-dependent manner (IC(50)=0.89muM). Video-electroencephalogram recordings demonstrated that following cortical administration of AcTx, animals showed behavioral changes, including tonic-clonic seizures, evolving into status epilepticus, accompanied by cortical epileptiform activity. Chemical characterization of AcTx showed that this compound is a nonproteic molecule with a molecular weight less than 500, differing from oxalic acid. This neurotoxic fraction of star fruit may be considered a new tool for neurochemical and neuroethological research.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.neuint.2005.02.002 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Cell elongation and altered phytohormone levels play a role in establishing distyly in Averrhoa carambola.
Gene
March 2025
Key Laboratory of National Forestry and Grassland Administration for Orchid Conservation and Utilization at College of Landscape Architecture, The Innovation and Application Engineering Technology Research Center of Ornamental Plant Germplasm Resources in Fujian Province, National Long Term Scientific Research Base for Fujian Orchid Conservation, Straits Flower Industry Highland, Fujian Agriculture and Forestry University, Fuzhou 350002, China. Electronic address:
The flowers of distylous plants exhibit two distinct morphologies that facilitate precise pollen transfer. Averrhoa carambola, a woody plant characterized by distyly, has an unclear molecular regulatory mechanism underlying this trait. Its prolonged flowering period and substantial flower production render it an excellent model for investigating the distylous syndrome.
View Article and Find Full Text PDFFruit Extract Mediated Formation of Luminescent Titanium Dioxide Nanometer-Sized Particles: An Innovative Strategy in Domain of Photodecomposition and Germicidal Properties.
Luminescence
November 2024
Department of Botany, Sri Vijay Vidyalaya College of Arts and Science (Women), Affiliated to Periyar University, Krishnagiri, India.
Discoveries in nanotechnologies are placing a great deal of attention on greener strategies that use harmless substances and moderated reactions to promote healthy development. This work used a straightforward, innovative, and cost-effective sustainable approach to produce bio-augmented TiO nanometer-sized particles (NMSP) by applying a water-based extract of the star fruit as a stabilization and reduction agent. A variety of techniques, comprising UV-Vis, XRD, FT-IR, FE-SEM with EDAX, and TEM, have been employed to investigate the formed TiO NMSP.
View Article and Find Full Text PDFDevelopmental Morphology, Physiology, and Molecular Basis of the Pentagram Fruit of .
Plants (Basel)
September 2024
Key Laboratory of National Forestry and Grassland Administration for Orchid Conservation and Utilization at College of Landscape Architecture and Art, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
, a key tropical and subtropical economic tree in the Oxalidaceae family, is distinguished by its unique pentagram-shaped fruit. This study investigates the developmental processes shaping the polarity of fruit and their underlying hormonal and genetic mechanisms. By analyzing the Y1, Y2, and Y3 developmental stages-defined by the fruit diameters of 3-4 mm, 4-6 mm, and 6-12 mm, respectively-we observed that both cell number and cell size contribute to fruit development.
View Article and Find Full Text PDFIdentification of key gene networks controlling organic acid and sugar metabolism during star fruit (Averrhoa carambola) development.
BMC Plant Biol
October 2024
The Innovation and Application Engineering Technology Research Center of Ornamental Plant Germplasm Resources in Fujian Province, National Long term Scientific Research Base for Fujian Orchid Conservation, Fujian Agriculture and Forestry University, Fuzhou, 350002, China.
The sugar and organic acid content significantly impacts the flavor quality of star fruit, and it undergoes dynamic changes during development. However, the metabolic network and molecular mechanisms governing the formation of sugar and organic acid in star fruit remain unclear. In this study, 23 of 743 components were detected by metabonomic analysis.
View Article and Find Full Text PDFEffect of edible coating of gelatin-sodium alginate with the addition of green tea (Camellia sinensis) extract on the characteristics of star fruit (Averrhoa carambola L.) during storage.
J Food Sci
October 2024
Department of Food and Agricultural Product Technology, Faculty of Agricultural Technology, Gadjah Mada University, Bulaksumur, Yogyakarta, Indonesia.
Article Synopsis
- Star fruit is nutritious but prone to damage, and edible coatings can help extend its shelf life.
- Researchers tested a gelatin-sodium alginate edible coating with varying concentrations of green tea to enhance star fruit's quality during storage.
- Results showed that the green tea-infused coating significantly reduced weight loss, maintained fruit integrity, improved vitamin C levels, and inhibited deterioration over 13 days.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!