Bullous pemphigoid (BP) is an acquired, pruritic, blistering eruption of the skin that typically presents as large, tense, subepidermal bullae in elderly persons. In this article, we present the case of an 80-year-old man with a 2-year history of generalized pruritus with occasional bullae in healed incision sites on his abdomen. Results of biopsy and direct immunofluorescence testing demonstrated evidence consistent with BP. This case demonstrated a BP flare in surgically treated skin, a phenomenon that has infrequently been reported in the literature.
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Br J Dermatol
January 2025
Department of Health Sciences, Section of Dermatology, University of Florence, Florence, Italy.
Front Immunol
January 2025
Department of Immunodermatology, National Medical Institute of the Ministry of the Interior and Administration, Warsaw, Masovian, Poland.
Linear IgA bullous dermatosis (LABD) is a rare subepidermal blistering disorder characterized by the presence of linear IgA deposits at the basement membrane zone (BMZ) by direct immunofluorescence (DIF). This entity was first described by Chorzelski and Jablonska from Warsaw Center of Bullous Diseases, Poland. The disease affects children and adults, whereby they differ in terms of clinical picture and course.
View Article and Find Full Text PDFMed J Armed Forces India
August 2022
Professor & Head (Dermatology), DY Patil Medical College & Research Centre, Pune, India.
Background: Autoimmune bullous disorder (AIBD) is a diverse group of blistering dermatoses that affects the skin and mucous membrane, characterized by the formation of autoantibodies against the desmosomal glycoproteins and adhesion molecular components of the basement membrane zone. Various immunoassay techniques for serological diagnosis are Direct Immunofluorescence (DIF), Indirect Immunofluorescence (IIF), Enzyme Linked Immunosorbent Assay (ELISA) and immunoblotting. Quantitative ELISA titer can also be used to monitor the disease activity and response to treatment.
View Article and Find Full Text PDFInt J Mol Sci
January 2025
Department of Dermatology, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.
Psoriasis is a chronic inflammatory condition that is polygenic and multisystemic, impacting approximately 2-3% of the global population. The onset of this disease is influenced by an intricate interplay of genetic and environmental factors, predisposing individuals to the psoriasis phenotype. The complex pathogenesis of psoriasis contains certain key aspects found in other autoinflammatory and autoimmune dermatological diseases.
View Article and Find Full Text PDFJ Eur Acad Dermatol Venereol
February 2025
2nd Dermatology Department, Center of Expertise on AIBD, Papageorgiou General Hospital, Aristotle University School of Medicine, Thessaloniki, Greece.
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