Targeted norfloxacin is active in vivo against persistent Mycobacterium bovis BCG.

J Control Release

Groupe de Pharmacocinétique des Prodrogues et Conjugués Macromoléculaires (INSERM), CRBA-UMR 5473 CNRS, Faculté de Pharmacie,15 avenue Charles Flahault, BP 14491, 34093 Montpellier cedex 5, France.

Published: January 2005

Download full-text PDF

Source

Publication Analysis

Top Keywords

targeted norfloxacin
4
norfloxacin active
4
active vivo
4
vivo persistent
4
persistent mycobacterium
4
mycobacterium bovis
4
bovis bcg
4
targeted
1
active
1
vivo
1

Similar Publications

AO-UBERRemoval of mixed antibiotics from saline wastewater under intermittent electrical stimulation and alterations of microbial communities and resistance genes.

Environ Res

January 2025

Key Laboratory of Oasis Ecology of Education Ministry, College of Ecology and Environment, Xinjiang University, Urumqi 830017, P.R. China; Xinjiang Jinghe Observation and Research Station of Temperate Desert Ecosystem, Ministry of Education, Urumqi 830017, P.R. China.

Antibiotics and antibiotic resistance genes (ARGs) are severe refractory pollutants in water. However, the effect of an intermittent electrical stimulation on the removal of antibiotics and ARGs from saline wastewater remains unclear. An anaerobic-aerobic-coupled upflow bioelectrochemical reactors (AO-UBERs) was used to treat tetracycline (TC) and quinolone (QN) in saline wastewater.

View Article and Find Full Text PDF

Bloodstream Infection Combined with Thoracic Infection Caused by : A Case Report and Review of the Literature.

Infect Drug Resist

December 2024

Department of Laboratory Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, People's Republic of China.

Objective: is usually found in urogenital tract infections and is associated with several extra-genitourinary infections, including septic arthritis, bacteremia, and meningitis. Here, we report a rare case of induced bloodstream infection with thoracic inflammation in a surgical patient.

Methods: A 56-year-old male who underwent surgery for multiple pelvic and rib fractures developed fever, pleural effusion, and wound exudation despite receiving prophylactic anti-infection treatment with cefotiam.

View Article and Find Full Text PDF

Molecular insights into the aspartate protease Plasmepsin II activity inhibition by fluoroquinolones: A pathway to antimalarial drug development.

Int J Biol Macromol

December 2024

UM-DAE Centre for Excellence in Basic Sciences, University of Mumbai, Vidyanagri Campus, Kalina, Mumbai 400098, India. Electronic address:

Plasmepsin II (PlmII) belongs to the aspartate proteases and is involved in hemoglobin degradation in Plasmodium falciparum. Due to its critical role in the survival of the Plasmodium, PlmII is considered as a potent drug target for antimalarial therapy. We have done recombinant protein production of pro-plasmepsin II (Pro-plmII).

View Article and Find Full Text PDF

Chaohu Lake is the fifth largest freshwater lake in China that meets the needs of surrounding industries for water, tourism, and flood storage, making it important for the socio-economic development and modernization of Anhui Province. As an important ecological wetland in the lower reaches of the Yangtze River, many rare bird habitats are present along the coast of Chaohu Lake. Therefore, it is eco-economically important to study antibiotic pollution in Chaohu Lake.

View Article and Find Full Text PDF

Proposed macroscopic quality indicators of antimicrobial stewardship in primary care: An observational study.

Infect Dis Now

December 2024

Hospital hygiene department, Besancon University Hospital, Besancon, France; UMR 6249 Chrono-environnement, University of Bourgogne Franche Comté, Besançon, France.

Article Synopsis
  • - The study aimed to assess how effective two macroscopic quality indicators are in improving antibiotic use strategies across the Bourgogne-Franche-Comté region from 2015 to 2020.
  • - Data on antibiotic prescriptions for urinary and respiratory infections were analyzed, revealing varying consumption rates among departments and a consistent increase in quality indicator scores, except for urinary infections in 2020 due to a medication shortage.
  • - The findings suggest that these quality indicators can effectively identify areas for improvement in antibiotic prescribing practices, helping general practitioners focus on community health needs without requiring detailed diagnostic information.
View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!