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Fabrication of bio-mimic nanozyme based on Mxene@AuNPs and molecular imprinted poly(thionine) films for creatinine detection.
Biosens Bioelectron
March 2025
Department of Cogno-Mechatronics Engineering, College of Nanoscience and Nanotechnology, Pusan National University, Busan, 46241, Republic of Korea. Electronic address:
Creatinine (Ctn) is a biomarker for chronic kidney disease (CKD). In this study, a highly sensitive and specific detection method for Ctn based on a molecularly imprinted polymer (MIP) based electrochemical biosensor was developed. Mxene (Mx), which has high absorption properties, was modified using carbon screen-printed electrodes (SPCE).
View Article and Find Full Text PDFState-of-the-Art Synthesis of Porous Polymer Materials and Their Several Fantastic Biomedical Applications: a Review.
Adv Healthc Mater
December 2024
Graduate Institute of Applied Science and Technology, National Taiwan University of Science and Technology, Taipei, Taiwan, 106, P. R. China.
Porous polymers, including hydrogels, covalent organic frameworks (COFs), and hyper crosslinked polymers (HCPs), have become essential in biomedical research for their tunable pore architectures, large surface areas, and functional versatility. This review provides a comprehensive overview of their classification and updated synthesis mechanisms, such as 3D printing, electrospinning, and molecular imprinting. Their pivotal roles in drug delivery, tissue engineering, wound healing, and photodynamic/photothermal therapies, focusing on how pore size, distribution, and architecture impact drug release, cellular interactions, and therapeutic outcomes, are explored.
View Article and Find Full Text PDFAn organic-inorganic polyacrylamide-based surface imprinted quantum dots for the impedimetric and voltammetric detection of diazepam in saliva with smartphone readout.
Talanta
December 2024
Leverhulme Research Centre for Forensic Science, School of Science and Engineering, University of Dundee, Dundee, DD1 4HN, UK.
Diazepam (DZP) is a muscle-relaxing, anxiety-relieving sedative drug; nonetheless, it is also an addictive drug that may be abused. This work reports on the development of a novel electrochemical nanosensor for diazepam using SiO-encapsulated-3-mercaptopropionic acid-capped AuZnCeSeS quantum dots (QDs) overcoated with a molecularly imprinted polymer (MIP) on screen-printed carbon electrodes (SPCEs). Electrochemical, spectroscopic and electron microscopic characterization of the nanomaterial and modified electrode surface was carried out and is reported herein.
View Article and Find Full Text PDFNanomolar detection of lurasidone hydrochloride in pharmaceutical formulations (Serodopamoun®) and spiked urine using a PVC/imprinted polymer/MWCNTs layer deposited onto polyaniline-coated screen-printed electrodes.
RSC Adv
December 2024
Department of Chemistry, Faculty of Science, Cairo University 12613 Giza Egypt
This study developed potentiometric sensors for detecting lurasidone HCl (LSH), a vital drug for treating schizophrenia and bipolar I disorder, in pharmaceutical formulations and biological samples. The sensors are based on screen-printed electrodes (SPE) modified with a molecularly imprinted polymer (MIP) synthesized using lurasidone as a template, 1-vinyl-2-pyrrolidine (VP) as a functional monomer, ethylene glycol dimethacrylate (EGDMA) as a crosslinker, and benzoyl peroxide as an initiator. The SPE was further modified with a conductive polyaniline (PANI) film and a polyvinyl chloride (PVC) layer containing MIP as an ionophore and multiwalled carbon nanotubes (MWCNT) as a transducing material along with 2-nitrophenyl octyl ether (2-NPOE) as plasticizer.
View Article and Find Full Text PDFTomographic ultrasound imaging of the anophthalmic socket for future 3D printing of ocular prostheses.
Orbit
November 2024
Ophthalmology, Department of Clinical Sciences Lund, Lund University, Skåne University Hospital, Lund, Sweden.
Purpose: There is a need for a simple, non-invasive, and easily accessible 3D imaging technique for the anophthalmic socket to create imaging data for future 3D printing of prostheses. This study aimed to investigate the feasibility of using a novel handheld tomographic ultrasound for 3D mapping of the anophthalmic socket.
Methods: Ten anophthalmic sockets were scanned using a tomographic ultrasound system and the results were compared to CT scanned impression molds from the same sockets.
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