A novel series of 2,6-diamino-3-acylpyridines were designed and synthesized as cyclin-dependent kinase (CDK) inhibitors. The representative compounds 2r and 11 showed potent CDK1 and CDK2 inhibitory activities and inhibited cellular proliferation in HeLa, HCT116, and A375 tumor cells.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.bmcl.2005.03.024 | DOI Listing |
Publication Analysis
Top Keywords
cyclin-dependent kinase
8
3-acyl-26-diaminopyridines cyclin-dependent
4
kinase inhibitors
4
inhibitors synthesis
4
synthesis biological
4
biological evaluation
4
evaluation novel
4
novel series
4
series 26-diamino-3-acylpyridines
4
26-diamino-3-acylpyridines designed
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!